Association Between Alleles of Cytokine Genes with Rheumatoid Arthritis in Russian Population
|Nataliya E Soroka1, Svetlana A Morozova1, Valery V Ilinsky2, Dmitry Y Trofi mov1 and Denis V Rebrikov1,2*|
|1DNA-Technology JSC, Kashirskoe shosse, 23-5-14, Moscow, 115478, Russia|
|2Institute of General Genetics of Russian Academy of Sciences, Gubkina str., 3, Moscow, 119991, Russia|
|Corresponding Author :||Denis V Rebrikov
Institute of General Genetics of Russian Academy of Sciences
Gubkina str., 3, Moscow, 119991, Russia
E-mail: [email protected]
|Received September 13, 2010; Accepted October 19, 2010; Published October 20, 2010|
|Citation: Soroka NE, Morozova SA, Ilinsky VV, Trofi mov DY, Rebrikov DV (2010) Association Between Alleles of Cytokine Genes with Rheumatoid Arthritis in Russian Population. J Clin Cell Immunol 1:102. doi:10.4172/2155-9899.1000102|
|Copyright: © 2010 Soroka NE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: Rheumatoid arthritis (RA) is a multi-factor disease with a key role of genetic component in its genesis. Development of osteoporosis and articular destruction is attributed with overexpression of pro-infl ammatory cytokines and reduced production of anti-infl ammatory ones. In this work probable associations of IFN-γ, IL-1α, IL-1β, IL-4, IL-6, IL-10, IL-18 and TNFα alleles with rheumatoid arthritis were studied among Russian ethnic group.
Methods: A total of 69 Russian ethnical group patients with RA (cases) and 133 healthy control individuals (controls) were genotyped for variants in 8 cytokines genes (IFN-γ, IL-1α, IL-1β, IL-4,IL-6, IL-10, IL-18 and TNFα). Individual genotype and haplotype frequencies were compared between cases and controls. Odd ratios were calculated with asymptotic 95% confi dence intervals and P values less than 0.05 were considered statistically signifi cant.
Results: The distribution of studied alleles of cytokine genes in Russian population is similar to other European populations. Genotype, allele and haplotype frequencies were equally distributed between RA cases and controls for IFN-γ (rs2430561), IL-1α (rs1800587), (rs17561), IL-1β (rs1143627), (rs16944), (rs1143634), IL-10 (rs1800871), IL- 18 (rs1946518) and TNFα (rs361525). Meanwhile, signifi cant associations (р<0.05) were found between RA cases and controls for IL-4 (rs2243250) T/T, IL-6 (rs1800795) G/G, IL-10 (rs1800872) A/A, IL-10 (rs1800896) G/A, IL-18 (rs187238) G/C and TNFα (rs1800629) G/A.
Conclusions: These results indicate that common variants of the IL-4, IL-6, IL-10, IL-18 and TNFα may signifi cantly contribute to RA susceptibility.