Association between Helicobacter pylori Infection and Idiopathic Thrombocytopenic Purpura in Adults
Takayoshi Suzuki*, Masashi Matsushima, Atsushi Takagi and Tetsuya Mine
Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
- Corresponding Author:
- Takayoshi Suzuki
Division of Gastroenterology & Hepatology
Department of Internal Medicine
Tokai University School of Medicine
259-1193, 143 Shimokasuya, Isehara, Kanagawa, Japan
E-mail: [email protected]
Received Date: February 10, 2014; Accepted Date: April 29, 2014; Published Date: May 07, 2014
Citation: Suzuki T, Matsushima M, Takagi A, Mine T (2014) Association between Helicobacter pylori Infection and Idiopathic Thrombocytopenic Purpura in Adults . J Blood Disord Transfus 5:212. doi:10.4172/2155-9864.1000212
Copyright: © 2014 Suzuki T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A Gram-negative spiral bacterium, Helicobacter pylori, has been known to be a causative agent of chronic gastritis and peptic ulcer disease and plays an important role in increasing the risk for the development of gastric cancer. In addition, the infection has also been implicated in the development of extragastric diseases, such as hematological, systemic, cardiovascular and neurological diseases. Accumulating evidence indicates that successful eradication of H. pylori results in an increase of the platelet count in approximately half of H. pylori-positive ITP patients. However, the efficacy of the eradication was quite different in ITP patients among different countries worldwide. In this review, we summarize the recent evidences with regard to the association between H. pylori infection and ITP. We also provide information about the possible pathogenetic mechanisms and the factors for predicting platelet recovery.