Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year StudyXuekui Liu1#, Jun Liang1,2#*, Qinqin Qiu1, Fei Teng1, Yu Wang1, Yan Zhu1, Ying Pei1 and Yuting Sun1
- *Corresponding Author:
- Dr. Jun Liang, MD, PhD
Department of Endocrinology
Xuzhou Central Hospital 199 South Jiefang Road
Xuzhou, Jiangsu, China
E-mail: [email protected]
Received date: January 11, 2017; Accepted date: January 23, 2017; Published date: January 30, 2017
Citation: Liu X, Liang J, Qiu Q, Teng F, Wang Y, et al. (2017) Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year Study. J Metabolic Synd 6:220. doi: 10.4172/2167-0943.1000220
Copyright: © 2017 Liu X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Non-alcoholic fatty liver disease (NAFLD) is recognized as a major cause of liver-related morbidity and mortality. The aim of this study was to examine the longitudinal association between baseline hematocrit (HCT) level and the development of NAFLD in Chinese adults. We performed a prospective cohort study of 2798 healthy Chinese adults without NAFLD at baseline. A Cox proportional hazards model was used to determine hazard ratios for NAFLD incidence in two groups determined by baseline hematocrit levels (group A, HCT <49%; group B, HCT ≥ 49%). During 10346.5 person-years of follow-up, 474 (16.9%) NAFLD cases developed between 2008 and 2012. After adjusting for multiple covariates and change in the covariates during the follow-up period, the hazard ratios (95% confidence interval) for NAFLD incidence when comparing group B with group A were 1.17 (1.03-1.31) and 1.70 (1.26-2.31), respectively (p<0.001).
Conclusions: HCT level may be a predictor of the development of NAFLD in Chinese adults.