alexa Association between Hepatitis B Virus and Celiac Disease Patients in Khartoum State, Sudan
ISSN: 2327-5073

Clinical Microbiology: Open Access
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Research Article

Association between Hepatitis B Virus and Celiac Disease Patients in Khartoum State, Sudan

Shiraz Gamal1*, Khalid Enan2, Mohammed Hussien2, Mustafa El-tigani1 and Isam Elkhidir3

1Department of Microbiology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan

2Central Laboratory, Ministry of Science and Technology Khartoum, Sudan

3Department of Microbiology and Parasitology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan

*Corresponding Author:
Shiraz Gamal
Department of Microbiology
Faculty of Medical Laboratory Sciences
Al Neelain University, Khartoum, Sudan
Tel: +249912170926
E-mail: [email protected]

Received Date: February 24, 2013; Accepted Date: March 27, 2013; Published Date: March 31, 2013

Citation: Gamal S, Enan K, Hussien M, El-tigani M, Elkhidir I (2013) Association between Hepatitis B Virus and Celiac Disease Patients in Khartoum State, Sudan. Clin Microbial 2:107. doi: 10.4172/2327-5073.1000107

Copyright: © 2013 Gamal S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: It has been hypothesized that non-intestinal inflammatory diseases such as hepatitis B virus (HBV) and hepatitis C virus (HCV) may trigger immunological gluten intolerance in susceptible people. This hypothesis suggests a possible epidemiological link between these two diseases. Method: ELISA third generation for Hepatitis B surface antigen (HBsAg) was used in 131 blood samples of patients with seropositive and seronegative for celiac disease (CD). Positive and negatives ELISA samples were confirmed using PCR for detection of HBV DNA. Data on various variables were collected from patients CD using a structured questionnaire after taking informed consent. Results: The prevalence of HBs Ag detected in seropositive celiac disease was 9.9% by serology (ELISA) and 8.5% using PCR. PCR detected two samples out of 64 (3.1%) as positive for HBV DNA which were negative by HBs Ag ELISA which indicated occult HBV infection. No statistical significant was difference (P > 0.05) among subjects when distribution of HBV was studied on the basis of age and gender. Conclusions: The results herein reported that there was an association between HBV and CD in the Khartoum State, Sudan as evident from the significantly higher prevalence of HBV infection in CD patients compared to CD seronegative patients included in the current study.

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