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Association between Paraoxonase 1 (PON1) and Suicidal Risk in Patients with Schizophrenia | OMICS International | Abstract
ISSN: 2378-5756

Journal of Psychiatry
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Research Article

Association between Paraoxonase 1 (PON1) and Suicidal Risk in Patients with Schizophrenia

Mensi Rym1,3*, Messaoud Ame1,3, Hellara Ilhem3, Amamou Badii1,2, Neffati Fadoua3, Douki Wahiba1,3, Najjar Mohamed Fadhel3 and Gaha Lotfi1,2

1Research Laboratory "Vulnerability to Psychotic Disorders" University of Monastir, Tunisian Republic, Tunisia

2Department of Psychiatry, University Hospital in Monastir, Tunisian Republic, Tunisia

3Clinical Biochemistry and Toxicology Laboratory, University Hospital in Monastir, Tunisian Republic, Tunisia

*Corresponding Author:
Mensi Rym
Research Laboratory "Vulnerability to Psychotic Disorders" University of Monastir
Tunisian Republic, Tunisia
Tel: +216 55935806
E-mail: [email protected]

Received Date: May 12, 2017; Accepted Date: June 06, 2017; Published Date: June 13, 2017

Citation: Rym M, Ame M, Ilhem H, Badii A, Fadoua N, et al. (2017) Association between Paraoxonase 1 (PON1) and Suicidal Risk in Patients with Schizophrenia. J Psychiatry 20: 424. doi:10.4172/2378-5756.1000424

Copyright: © 2017 Rym M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: There have been many studies on psychiatric disorders, but very little is known about the biology of suicide with schizophrenia. In the present study, we are looking for a possible connection between paraoxonase 1 (PON1) and suicidal behavior in schizophrenic Tunisian patients. Methods: Assay of PON1 has been done for 170 schizophrenic patients with and without suicide attempts and 119 healthy controls. All patients enrolled in the study were evaluated by psychometric scales (PANSS, EGF, CGI, BPRS and CALGARY). Results:In our study, a significant decrease in the enzymatic activity of PON1 was found in schizophrenia patients compared to controls. PON1 was also significantly lower in schizophrenic patients with suicide attempt compared to those without suicide attempt. In our work, a weak correlation between the psychometric scale CGI severity of the disease, PON1 activity and suicidal act was found. Conclusions:Results of this study showed that PON 1 levels in schizophrenic patients after suicide attempt was significantly lower than in patients with suicide attempt. PON1 may be one of the biological markers of susceptibility to suicide in patients with schizophrenia.