Association between Red Cell Distribution Width and Disease Activity in Patients with Behcet’s Disease
|Semra Aktürk1, Erdal Aktürk2*, ErtuÃ„ÂŸrul KurtoÃ„ÂŸlu3, Arzu Kaya1, Arif Gülkesen1, Gül Ayden Kal1, Türkan Tuncer1 and Ã„Â°sa Sincer4|
|1Firat University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, ElazÃ„Â±Ã„ÂŸ, Turkey|
|2Adiyaman University, Faculty of Medicine, Department of Cardiology, Adiyaman, Turkey|
|3ElazÃ„Â±Ã„ÂŸ Education and Research Hospital, Department of Cardiology, ElazÃ„Â±Ã„ÂŸ, Turkey|
|4Gaziantep State Hospital, Department of Cardiology, Gaziantep, Turkey|
|Corresponding Author :||Erdal Aktürk, MD
Department of Cardiology
Adiyaman University, Adiyaman, Turkey
Tel: +0090 422 3410660, ext. 4500
Fax: +0090 422 3412708
E-mail: [email protected]
|Received: August 08, 2012; Accepted: August 24, 2012; Published: August 27, 2012|
|Citation: Aktürk S, Aktürk E, KurtoÃ„ÂŸlu E, Kaya A, Gülkesen A, et al. (2012) Association between Red Cell Distribution Width and Disease Activity in Patients with Behcet’s Disease. J Clin Exp Cardiolog 3:211. doi:10.4172/2155-9880.1000211|
|Copyright: © 2012 Aktürk S, et al. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Aims: we aimed to investigate whether red cell distribution width (RDW) can also be used for the assessment of disease activity in Behcet’s disease (BD).
Methods and results: Forty patients with active BD and seventy patients with inactive BD were included in the study. Forty-six healthy volunteers constituted the control group. Hematological parameters, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were analyzed by standard methods. All the individuals underwent comprehensive echocardiographic examination.
Echocardiographic parameters of the study population were similar all groups. ESR, CRP and RDW were significantly higher in active BD patients than in inactive BD patients and controls (33.6±22 vs 15.7±9 vs 5±4.1, 23.4±21.6 vs 5.5±6.2 vs 1.2±0.5 and 17.2±2.5 vs 14.4±1.9 vs 13.2±0.5, p<0.0001 for all, respectively). Moreover, we also found that ESR, CRP and RDW were significantly higher in inactive BD patients when compared with the controls (15.7±9 vs 5±4.1, 5.5±6.2 vs 1.2±0.5 and 14.4±1.9 vs 13.2±0.5, p<0.0001 for all, respectively). There were modest positive correlations between RDW and disease duration (r=0.320, P=0.001).
Conclusion: We demostrated that RDW significant increased in active and inactive BD patients without cardiac involvement. In addition, our study has established that RDW can be used to determine the disease activity state of BD.