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ISSN: 2378-5756

Journal of Psychiatry
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Research Article

Association between the SAT-1 Gene and Suicidal Behavior in Mexican Population

Carlos Alfonso Tovilla-Zárate1*, María Lilia López-Narváez2, Thelma Beatriz González-Castro3, Isela Juárez-Rojop4, Sherezada Pool-García5,Alma Genis6, Jorge Ble-Castillo4, Ana Fresán7 and Humberto Nicolini6

1Universidad Juárez Autónoma de Tabasco, Liga Académica Multidisciplinaria the Comalcalco, Comalcalco, Tabasco, México

2Hospital General de Yajalón, Secretaría de Salud, Yajalón, Chiapas, México

3Universidad Juárez Autónoma de Tabasco, Liga Académica Multidisciplinaria the Jalpa de Mendez, Cunduacán, Tabasco, México

4Universidad Juárez Autónoma de Tabasco, Liga Académica de Ciencias de la Salud, Villahermosa, Tabasco, México

5Hospital General de Comalcalco, Tabasco, Secretaría de Salud, Comalcalco, Tabasco, México

6Instituto Nacional de Medicina genomics (INMEGEN), Servicios de Atención Psiquiátrica (GSP), Secretaría de Salud, México, D. F, México

7Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatria Ramón de la Fuente Muñiz, México, DF México

*Corresponding Author:
Carlos Alfonso Tovilla Zárate
Universidad Juárez Autónoma de Tabasco
Liga Académica Multidisciplinaria the Comalcalco
Ranchería Sur Cuarta Sección, CP 86650
Comalcalco, Tabasco, México
Tel: 5219933581500
E-mail: [email protected]

Received date: March 26, 2015; Accepted date: May 30, 2015; Published date: June 06, 2015

Citation: Tovilla-Zárate CA, López-Narváez ML, González-Castro TB, Juárez-Rojop I, Pool-García S, et al. (2015) Association between the SAT-1 Gene andSuicidal Behavior in Mexican Population. J Psychiatry S1:005 doi: 10.4172/2378-5756.S1-005

Copyright: © 2015 Tovilla-Zárate CA, et al. This is an open-access articledistributed under the terms of the Creative Commons Attribution License, whichpermits unrestricted use, distribution, and reproduction in any medium, providedthe original author and source are credited

Abstract

Objective: The gene coding for spermidine/spermine N1-acetyltransferase 1 (SAT-1) participates in the metabolic pathways of polyamines as a rate-limiting enzyme; this gene is involved in regulating polyamine levels and it has been considered a candidate gene for suicidal behavior. The aim of this study was to determine the association between SAT-1 polymorphism A-1537C (rs6526342) and suicidal behavior, in a sample of suicide attempt patients in the Mexican population.

Methods: To observe the association between rs6526342 and suicidal behavior, we evaluated 169 unrelated suicide attempters and compared them to 218 non-suicidal individuals. Patients were evaluated by a trained psychiatrist or clinical psychologist. SAT-1 rs6526342 genotypes were analyzed using the polymerase chain reaction end-point method.

Results: No significant association was observed between cases and comparison group for allele frequency (p=0.40, df=1, p=0.69). However, a significant association between rs6526342 and suicidal behavior was observed in the male group for allele distribution (χ2=4.0, df=1, p=0.04, OR 0.48; 95% CI: 0.24-0.98), whereas in the female group, no association was found by genotype (χ2= 2.85, df=2, p=0.23) or allele (χ2=0.01, df=1, p=0.91) frequency.

Conclusion: Our results showed an association between allele C of the polymorphism in the promoter region of SAT-1 A-1537C (rs6526342) and suicidal behavior in Mexican males. This suggests that the SAT-1 gene may contribute to the risk for suicidal behavior among the Mexican population.

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