Association between the SAT-1 Gene and Suicidal Behavior in Mexican PopulationCarlos Alfonso Tovilla-Zárate1*, María Lilia López-Narváez2, Thelma Beatriz González-Castro3, Isela Juárez-Rojop4, Sherezada Pool-García5,Alma Genis6, Jorge Ble-Castillo4, Ana Fresán7 and Humberto Nicolini6
- *Corresponding Author:
- Carlos Alfonso Tovilla Zárate
Universidad Juárez Autónoma de Tabasco
Liga Académica Multidisciplinaria the Comalcalco
Ranchería Sur Cuarta Sección, CP 86650
Comalcalco, Tabasco, México
E-mail: [email protected]
Received date: March 26, 2015; Accepted date: May 30, 2015; Published date: June 06, 2015
Citation: Tovilla-Zárate CA, López-Narváez ML, González-Castro TB, Juárez-Rojop I, Pool-García S, et al. (2015) Association between the SAT-1 Gene andSuicidal Behavior in Mexican Population. J Psychiatry S1:005 doi: 10.4172/2378-5756.S1-005
Copyright: © 2015 Tovilla-Zárate CA, et al. This is an open-access articledistributed under the terms of the Creative Commons Attribution License, whichpermits unrestricted use, distribution, and reproduction in any medium, providedthe original author and source are credited
Objective: The gene coding for spermidine/spermine N1-acetyltransferase 1 (SAT-1) participates in the metabolic pathways of polyamines as a rate-limiting enzyme; this gene is involved in regulating polyamine levels and it has been considered a candidate gene for suicidal behavior. The aim of this study was to determine the association between SAT-1 polymorphism A-1537C (rs6526342) and suicidal behavior, in a sample of suicide attempt patients in the Mexican population.
Methods: To observe the association between rs6526342 and suicidal behavior, we evaluated 169 unrelated suicide attempters and compared them to 218 non-suicidal individuals. Patients were evaluated by a trained psychiatrist or clinical psychologist. SAT-1 rs6526342 genotypes were analyzed using the polymerase chain reaction end-point method.
Results: No significant association was observed between cases and comparison group for allele frequency (p=0.40, df=1, p=0.69). However, a significant association between rs6526342 and suicidal behavior was observed in the male group for allele distribution (χ2=4.0, df=1, p=0.04, OR 0.48; 95% CI: 0.24-0.98), whereas in the female group, no association was found by genotype (χ2= 2.85, df=2, p=0.23) or allele (χ2=0.01, df=1, p=0.91) frequency.
Conclusion: Our results showed an association between allele C of the polymorphism in the promoter region of SAT-1 A-1537C (rs6526342) and suicidal behavior in Mexican males. This suggests that the SAT-1 gene may contribute to the risk for suicidal behavior among the Mexican population.