alexa Association between the Severity of Tramadol Toxicity and Some CYP2D6 Allelic Variants in Egyptian Tramadol Intoxicated Patients
ISSN: 2165-7548

Emergency Medicine: Open Access
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Research Article

Association between the Severity of Tramadol Toxicity and Some CYP2D6 Allelic Variants in Egyptian Tramadol Intoxicated Patients

Samah F Ibrahim1*, Mona M Ali1, Ahmed S Gouda2 and Laila A Rashed3

1Forensic Medicine and Clinical Toxicology-Cairo University, Egypt

2Department of Toxicology at National Environmental Center of Toxicological Research- Cairo University, Egypt

3Department of Biochemistry- Cairo University, Egypt

*Corresponding Author:
Samah F. Ibrahim
Assistant professor of Forensic Medicine and Clinical Toxicology
Princess Nourah bint Abdulrahman University, Egypt
[email protected]

Received Date: November 17, 2015; Accepted Date: Decemberr 17, 2015; Published Date: December 24, 2015

Citation: Ibrahim SF, Ali MM, Gouda AS, Rashed LA (2015) Association between the Severity of Tramadol Toxicity and Some CYP2D6 Allelic Variants in Egyptian Tramadol Intoxicated Patients. Emergency Med 6:303. doi:10.4172/2165-7548.1000303

Copyright: © 2015 Ibrahim SF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Cytochrome P450 gene polymorphism is involved in the metabolism of tramadol. We investigated the effect of CYP2D6 gene polymorphism on tramadol metabolism by studying CYP2D6*1, CYP2D6*DUP, CYP2D6*4, and CYP2D6*10. CYP2D6 genotyping was performed using the xTAG CYP2D6 Kit v3 which incorporates multiplex PCR (Luminex kit). Tramadol levels were assessed using enzyme immunoassay. Our Study was done on 100 Egyptian patients with acute tramadol intoxication and 100 healthy control subjects. The patients were admitted to NECTR center. CYP2D6*1 was the most presented allelic variant in both groups The CYP2D6*DUP is associated with severe intoxication. There was a significant association between CYP2D6 allelic variants and tramadol metabolites level. In conclusion, our data suggests that studying CYP2D6 allelic variants may help clinicians to predict the severity of tramadol intoxication and individualize the drug treatment.


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