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ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
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Review Article

Association of ABO Blood Group and Risk of Breast Cancer

Rabab Aly1*, Ansaf Yousef2 and Omer Elbably3

1Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

2Internal Medicine Departement, Mansoura University, Mansoura, Egypt

3Faculty of Medicine, Mansoura University, Mansoura, Egypt

Corresponding Author:
Rabab Aly
Department of Clinical Pathology, Faculty of Medicine
Mansoura Universit, Mansoura, Egypt
Tel: +20 50 2383781
E-mail: [email protected]

Received Date: October 12, 2014; Accepted Date: November 29, 2014; Published Date: December 05, 2014

Citation: Aly R, Yousef A, Elbably O (2014) Association of ABO Blood Group and Risk of Breast Cancer. J Blood Disord Transfus 5:241. doi: 10.4172/2155-9864.1000241

Copyright: © 2014 Aly R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

ABO blood type has been observed in previous studies to be associated with the risk of certain malignancies, including pancreatic and gastric cancer. Our aim is to explore the possible relationships between blood groups and characteristics of patients and whether it is associated with the risk of breast cancer. Our study consisted of 160 breast cancer patients with serologically confirmed ABO blood group. A group of 92 healthy blood donors was identified as a control group. Overall distribution of ABO blood groups was comparable between patients (53.1% A, 21.8% O, 17.5% B and 7.5% AB) and controls (39.1% A, 32.6% O, 18.4% B and 9.7% AB). There were no significant differences in clinicopathologic characteristics among patients with different ABO blood groups. We found that patients with A blood group was positively associated with the risk of breast cancer (adjusted Odds Ratio=2.13, 95% Confidence Interval=1.04-2.96, P=0.03). We conclude that A blood type was associated with increased the risk of breast cancer and it might increase the probability to generate high-risk individuals if further studies confirm the present preliminary findings.

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