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Association of Alpha-2 Beta-1 Integrin Polymorphism with Retinopathy in Diabetic Patients | OMICS International | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Association of Alpha-2 Beta-1 Integrin Polymorphism with Retinopathy in Diabetic Patients

Nadeem Afzal1*, Nagi AH2, Muhammad Imran3, Abu Zafar4, Amtul Musawar5, Romeeza Tahir1, Sarwar Abbas1, Afia Abbas1, Shakeela Zaman6 and Shah Jahan1

1Department of Immunology, University of Health Sciences, Lahore, Pakistan

2Department of Pathology, University of Health Sciences, Lahore, Pakistan

3Centre for Research in Endocrinology and Reproductive Sciences, Department of Physiology and Cell Biology, University of Health Sciences, Pakist

4Amin Hayat Memorial Diabetic Centre, Lahore, Pakistan

5Services Hospital, Lahore, Pakistan

6Children Hospital and Institute of Child Health, Lahore, Pakistan

*Corresponding Author:
Nadeem Afzal
Associate Professor, Head
Department of Immunology
University of Health Sciences
Lahore, Pakistan
Tel: 92-321-4086-452
Fax: 92-42-99230870
E-mail: [email protected], [email protected]

Received date: September 25, 2012; Accepted date: October 25, 2012; Published date: October 30, 2012

Citation: Afzal N, Nagi AH, Imran M, Zafar A, Musawar A, et al. (2012) Association of Alpha-2 Beta-1 Integrin Polymorphism with Retinopathy in Diabetic Patients. J Diabetes Metab 3:223. doi:10.4172/2155-6156.1000223

Copyright: © 2012 Afzal N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Aim: Diabetes mellitus (DM) is a health concern because it leads to complications such as retinopathy and nephropathy. Pakistan has 6.9 million DM affected people that will be doubled by 2025. A study was designed to determine the role of genetics in diabetic retinopathy in Pakistani type 2 diabetes mellitus (T2DM) patients.

Material and methods: It was a cross-sectional case-control study that included 236 subjects, divided into Group I (54 volunteers without diabetes), Group II (30 T2DM patients without retinopathy) and Group III (152 T2DM patients with retinopathy). A BglII polymorphism of α2β1 integrin gene was genotyped in all these individuals by using RFLP method.

Results: The frequency of BglII polymorphism (++ and +-) genotypes was found significantly different between group I and group III individuals.

Conclusion: BglII (+/+, +/-) genotypes, gender of subject, age at the onset of diabetes, and duration of diabetes is associated with development of diabetic retinopathy in Pakistani T2DM patients.


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