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ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
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  • Research Article   
  • J Bioanal Biomed 2017 9: 294,
  • DOI: 10.4172/1948-593X.1000196

Association of Biochemical Parameters with Renal Functions of End Stage Renal Disease (ESRD) Patients of Bangladesh

Md Shohel Hossain1*, Khondokar Md Akter-Uz-Zaman1, Mohammad Nurul Amin2, Rubel Ahammed1, Md Emdadul Haque1, Md Ibrahim2, Md Lukman Hakim3, Dos Mohammad4, Md Alamgir Kabir5, Md Saiful Islam Arman1, Ummay Hanni2 and Mohammad Safiqul Islam6*
1Department of Pharmacy, Manarat International University, Dhaka, Bangladesh
2Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
3Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh
4Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Dhaka, Bangladesh
5Department of Psychology, University of Dhaka, Dhaka, Bangladesh
6Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh
*Corresponding Author (s) : Md Shohel Hossain, Lecturer, Department of Pharmacy, Manarat International University, Dhaka-1212, Bangladesh, Tel: +8802-9022164, Fax: +88-9862226, Email: [email protected]
Mohammad Safiqul Islam, Professor, Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh, Tel: +8801727658650, Email: [email protected]

Received Date: Oct 24, 2017 / Accepted Date: Nov 30, 2017 / Published Date: Dec 11, 2017

Abstract

Biochemical parameters are greatly influenced by genetic, physiological and environmental factors. Regional data is essential to establish a relationship between End stage renal disease (ESRD) and biochemical parameters. In Bangladesh, there is not any established research data on biochemical parameters of ESRD patient. The present study was a case control study with 500 ESRD patients and equal number of healthy volunteers (controls). Sociodemographic, anthropometric and clinical data of both patients and controls were collected. Serum biochemical parameters were analyzed by laboratory test. Statistical software package SPSS were used for independent sample t-test and Pearson’s correlation test. Our study found that serum creatinine, blood urea nitrogen (BUN) and serum uric acid were significantly higher (p<0.05) and serum potassium were significantly lower in ESRD patient as compared to control subjects (p<0.05). But serum chloride, serum sodium and serum calcium level were in the normal range. Pearson correlation analysis reveals that serum creatinine and serum chloride was inversely correlated with GFR (glomerular filtration rate) in both patient and control groups. This study explored that ESRD patients have higher level of serum creatinine, BUN and serum uric acid but lower level of serum potassium than normal patient. Routine investigation of serum biochemical parameters may help to prevent ESRD complication.

Keywords: Serum creatinine; Blood urea nitrogen (BUN); End Stage Renal Disease (ESRD)

Citation: Hossain MDS, Akter-Uz-Zaman KMD, Amin MN, Ahammed R, Haque MDE, et al. (2017) Association of Biochemical Parameters with Renal Functions of End Stage Renal Disease (ESRD) Patients of Bangladesh. J Bioanal Biomed 9: 294-298. Doi: 10.4172/1948-593X.1000196

Copyright: © 2017 Hossain MDS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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