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Association of Butyric Acid Produced by Periodontopathic Bacteria with Progression of Oral Cancer | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

Association of Butyric Acid Produced by Periodontopathic Bacteria with Progression of Oral Cancer

Yuji Miyazaki*, Kentaro Kikuchi1, Patricia González-Alva1, Harumi Inoue1, Yoshihiro Noguchi1, Hozumi Tsuchiya1, Joichiro Hayashi2, Kitetsu Shin2, Kuniyasu Ochiai3, and Kaoru Kusama1

1Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyaki-dai, Sakado, Saitama, Japan.

2Division of Periodontology, Department of Oral Biology & Tissue Engineering, Meikai University School of Dentistry, 1-1 Keyaki-dai, Sakado, Saitama, Japan.

3Department of Microbiology, Nihon University School of Dentistry, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo, Japan.

*Corresponding Author:
Dr. Yuji Miyazaki
Division of Pathology
Department of Diagnostic and Therapeutic Sciences
Meikai University School of Dentistry, 1-1 Keyaki-dai, Sakado
Saitama 350-0283, Japan
Fax: +81-49-286- 6101
Tel: +81-49-279-2773
E-mail: [email protected]

Received Date:February 20, 2010; Accepted Date: March 29, 2010; Published Date: March 29, 2010

Citation: Miyazaki Y, Kikuchi K, González-Alva P, Inoue H, Noguchi Y, et al. (2010) Association of Butyric Acid Produced by Periodontopathic Bacteria with Progression of Oral Cancer. J Cancer Sci Ther 2:026-032. doi: 10.4172/1948-5956.1000019

Copyright: © 2010 Miyazaki Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: The association between periodontal disease and the risk of various human cancers including oral squamous cell carcinoma (OSCC) has been suggested. Butyric acid (BA), an extracellular metabolite from periodontopathic bacteria, plays an important role in the progression of periodontal disease. Recent studies have shown that podoplanin, a transmembrane glycoprotein, is expressed in various normal as well as neoplastic tissues. In this study, the effects of BA/sodium butyrate (NaB) on podoplanin expression, cell migration and epithelial-mesenchymal transition in OSCC cell lines were examined. Methods: Ca9-22, HSC-2, -3 and -4 cells were incubated with NaB, and then subjected to real-time RT-PCR, western blotting and scratch assay. Results: NaB increased the expression of podoplanin in HSC-2 and -3 cells and vimentin in Ca9-22 cells. Cell migration was promoted at a low concentration of NaB especially in HSC-3 cells, whereas it was inhibited in HSC-2 and -4 cells. Scratch assay of HSC-2, -3 and -4 revealed that cell migration was markedly inhibited by addition of a siRNA specific for podoplanin . Conclusion: BA/NaB increases podoplanin expression and cell migration in certain OSCC cell lines, suggesting that the progression of periodontal disease may promote the progression of OSCC via a podoplanin-dependent pathway

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