Association of Circulating Fasting TNF-ÃÂ with Hyperglycemia is Stronger than with Body Mass Index in Newly Diagnosed Bangladeshi Type 2 Diabetic Subjects
- *Corresponding Author:
- Omar Faruque
Associate Professor, Bangladesh University of Health Sciences
Physiology & Molecular Biology, 125/1 Darus Salam
Mirpur-1, Dhaka, Bangladesh
Tel: 880 1797091813
E-mail: [email protected]
Received date: May 05, 2014; Accepted date: September 10, 2014; Published date: September 18, 2014
Citation: Faruque O, Biswas S, Kamaluddin SM, Saiedullah M, Rahman M, et al. (2014) Association of Circulating Fasting TNF-α with Hyperglycemia is Stronger than with Body Mass Index in Newly Diagnosed Bangladeshi Type 2 Diabetic Subjects. J Diabetes Metab 5:429. doi: 10.4172/2155-6156.1000429
Copyright: © 2014 Faruque O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background and aim: Insulin resistance and hypo-insulinemia are the major problems in Type 2 Diabetes Mellitus (T2DM). Epidemiological evidences suggest that obesity is linked with insulin resistance. Inflammatory cytokines such as TNF-α has also been associated with obesity and insulin resistance. The present study aims to evaluate fasting serum TNF-α in newly diagnosed type 2 diabetic subjects in different BMI group to observe its association with insulin sensitivity and obesity.
Methods: A total number of 145 newly diagnosed T2DM subjects were recruited in this study. On a prescheduled morning fasting and postprandial (2hrs after 75g glucose load) blood was drawn. Serum glucose was measured by glucose-oxidase method, lipid profile by enzymatic end-point method, insulin and TNF-α by ELISA methods. Insulin secretory capacity (HOMA%B) and insulin sensitivity (HOMA%S) were calculated using fasting glucose and insulin by HOMA-CIGMA software. SPSS for Windows was used for statistical analysis.
Results and conclusion: The subjects were divided into three groups on the basis of BMI cut-off points suggested by WHO for the Asian population (Gr1: BMI < 23, Gr2: BMI 23.1-27.5, Gr3: BMI>27.5). The fasting serum insulin and TNF-α levels were significantly (p<0.005) higher in group 3 than the other groups. HOMA%B was significantly higher in Gr 3 and HOMA%S was significantly lower in group 3 compared to group 1 and group 2. From multiple linear regression analysis it can be concluded that both BMI and postprandial serum glucose had potential effects on serum TNF-α level but the later one had stronger.