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ISSN: 2153-0602

Journal of Data Mining in Genomics & Proteomics
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Research Article

Association of G1691A Mutation in Women with Breast Cancer

Shaik Nazia Tabassum1*, Salina Y Saddick2

1Department of Pharmacy Practice, Browns College of Pharmacy, Telangana, India

2Department of Biology, King Abdul Aziz University, Jeddah, Saudi Arabia

*Corresponding Author:
Dr. Shaik Nazia Tabassum
Department of Pharmacy Practice
Browns College of Pharmacy
Khammam 507305, Telangana, India
Tel: 00918742282799
Fax: 00918742282799
E-mail: [email protected]

Received date: April 27, 2014; Accepted date: June 30, 2014; Published date: July 08, 2014

Citation: Tabassum SN, Saddick SY (2014) Association of G1691A Mutation in Women with Breast Cancer. J Data Mining Genomics Proteomics 5:160. doi:10.4172/2153-0602.1000160

Copyright: © 2014 Tabassum SN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

 Objectives: More evidence indicates that the G1691A mutation in the factor V Leiden (FVL) gene might be associated with susceptibility to breast cancer in humans being. Breast cancer is gradually becoming the most common cancer in Indian women, pathogenesis can be influenced by single nucleotide polymorphisms and several studies in the past have identified different genetic variants in the human genome that showed strong or moderate evidence of associations. FVL is a missense mutation, result of an amino acid substitution of glutamine for arginine at 506 position in the factor V molecule at nucleotide 1691 substitutes G for A, resulting in a mutant protein resistant to the anticoagulant action of activated protein C.

Methods: We aimed to investigate the role of G1691A mutation in FVL gene and breast cancer women from south Indian population. One hundred cases and 100 controls were included in this study. DNA was separated and PCR-RFLP was performed followed by 2% electrophoresis.

Results: The results of this study indicates that FVL mutation is associated with breast cancer patients (p<0.05).
 
Conclusion: Our results concluded that FVL mutation has a role in breast cancer women and these results are supported by prior studies.

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