Association of Helicobacter Pylori Infection with Oxidative DNA Damage and Atherosclerosis in Rheumatoid Arthritis PatientsDoaa Waseem Nada1, Amal Mohamad El-Barbary1*, Sally Abd El monem El Nawasany 2, Rasha Ahmed Gaber3, Radwa Mahmoud El-sharaby4, Muhammad Tarek Abdel Ghafar4 and Hossam Abdelhafiz Zaytoun5
- *Corresponding Author:
- Amal Mohamad El-barbary
Assistant Professor of Rheumatology and Rehabilitation Department
Tanta University, Egypt
Email: [email protected]
Received date: December 27, 2017; Accepted date: March 13, 2017; Published date: March 25, 2017
Citation: Nada DW, El-Barbary AM, El Nawasany SE, Gaber RA, El-sharaby RM, et al. (2017) Association of Helicobacter Pylori Infection with Oxidative DNA Damage and Atherosclerosis in Rheumatoid Arthritis Patients. J Arthritis 6:234. doi: 10.4172/2167-7921.1000234
Copyright: © 2017 Nada DW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objectives: to evaluate the associations between Helicobacter pylori (HP) with oxidative DNA damage and subclinical atherosclerosis in rheumatoid arthritis (RA) patients.
Methods: Eighty RA patients were divided into two groups according to the presence of anti-HP antibodies. In addition, to forty healthy volunteers. All patients were subjected to DAS-28, ESR , hsCRP ,RF, Anti-CCP, Lipid profiles, serum anti-HP antibodies, 8-hydroxydeoxyguanosine, Oxidized LDL, IL-6,carotid intima media thickness (cIMT) and flow mediated dilatation of the brachial artery (FMD).
Results: HP positive RA patients revealed significantly higher disease activity, RF, Anti-CCP, dyslipidemia, 8- OHdG, ox-LDL, cIMT and lower FMD% compared to HP negative patients. There was positive correlation between anti-HP antibodies with disease activity parameters, ox-LDL, 8-OHdG and cIMT as well as negative correlation with FMD℅. In multiple regression analysis, IgG antibodies against H pylori were associated with DAS-28 (p=p<0.001), hsCRP (p=p<0.01), 8-OHdG (p<0.01), cIMT (p<0.001) and FMD℅. (p<0.001).
Conclusions: Chronic infection with HP in RA patients is significantly associated with oxidative stress and DNA damage. Detection and eradication of HP infection in RA patients may reduce the burden of atherosclerosis and its associated morbidity and mortality.