alexa Association of hOGG1 Ser326Cys, ITGA2 C807T and TNF-A -308Gandgt;A Polymorphisms with the Risk of NPC | OMICS International| Abstract
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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  • Research Article   
  • J Mol Genet Med 2017, Vol 11(4): 314
  • DOI: 10.4172/1747-0862.1000314

Association of hOGG1 Ser326Cys, ITGA2 C807T and TNF-A -308G>A Polymorphisms with the Risk of NPC

Eng-Zhuan B1, Munn-Sann L1*, Chong PP2, Yoke-Yeow Y3, Siew-Ying CL4 and Rahman HA1
1Faculty of Medicine and Health Sciences, Department of Community Health, Universiti Putra Malaysia, Serdang, Malaysia
2Faculty of Medicine and Health Sciences, Department of Biomedical Sciences, Universiti Putra Malaysia, Serdang, Malaysia
3Faculty of Medicine and Health Sciences, Department of Otorhinolaryngology, Universiti Putra Malaysia, Serdang, Malaysia
4Faculty of Applied Sciences, UCSI University, Cheras, Malaysia
*Corresponding Author : Munn-Sann L, Faculty of Medicine and Health Sciences, Department of Community Health, Level 1, Block B (Academic), Universiti Putra 43400, UPM Serdang, Selangor, Malaysia, Tel: +60389472410, Email: [email protected]

Received Date: Dec 08, 2017 / Accepted Date: Dec 28, 2017 / Published Date: Dec 29, 2017

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a rare form of cancer. NPC is the 4th most common cancer in Malaysia and the incidence rate for Malaysian Chinese is exceptionally high compared to other races. NPC is considered as a relatively radiosensitive tumor and patients diagnosed at early stages tend to survive longer compared to those who with advanced disease. Given that early symptoms of NPC are non-specific, and that the nasopharynx is relatively inaccessible, less invasive screening methods such as biomarker screening might be the key to improve NPC survival and management. Methodology: A matched case-control study was conducted to investigate the effect of hOGG1 Ser326Cys, ITGA2 C807T and TNF-α -308G>A polymorphisms on the risk of nasopharyngeal carcinoma and all-cause survival. hOGG1 gene encodes for a DNA glycosylase, a protein that is involved in DNA repair. ITGA2 is the alpha subunit of the transmembrane receptor integrin and is mainly responsible for cell-cell and cell-extracellular matrix interaction. TNF-α is a cytokine that is released by immune cells during inflammation. Restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) was used to process DNA genotyping studies involving all aforementioned gene polymorphisms. Conditional logistic regression was used for the analysis of NPC risk on gene polymorphisms, controlling for cigarette smoking, salted fish and alcohol consumption. Results: Conditional logistic regression showed that NPC cases were more likely to ever consume salted fish during childhood compared to controls (OR=1.80, 95% CI=1.32-2.46, p<0.01). Individuals with previous smoking history were also at higher risk of NPC (OR=1.96, 95% CI=1.37-2.81, p<0.01). No significant difference was found between NPC cases and controls for alcohol consumption. No significant association was observed between hOGG1 Ser326Cys, ITGA2 C807T, TNF-α -308G>A polymorphisms with NPC risk. Conclusion: None of the aforementioned polymorphisms showed significant association in increasing NPC risk individually.

Keywords: hOGG1 Ser326Cys, ITGA2 C807T, TNF-A -308G, NPC, Polymorphism

Citation: Eng-Zhuan B, Munn-Sann L, Chong PP, Yoke-Yeow Y, Siew-Ying CL, et al. (2017) Association of hOGG1 Ser326Cys, ITGA2 C807T and TNF-A -308G>A Polymorphisms with the Risk of NPC. J Mol Genet Med 11: 314. Doi: 10.4172/1747-0862.1000314

Copyright: © 2017 Eng-Zhuan B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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