alexa Association of Human Leukocyte Antigens Class I and II Variants with Susceptibility to Pulmonary Tuberculosis in a Caucasian Population from Northern Spain
ISSN: 2161-1068

Mycobacterial Diseases
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Association of Human Leukocyte Antigens Class I and II Variants with Susceptibility to Pulmonary Tuberculosis in a Caucasian Population from Northern Spain

Gonzalo Ocejo-Vinyals J1*, Fernando Ausín1, Elena Puente de Mateo1, José Luis Arroyo2, Ramón Agüero3, Diego Ferrer3, Carmen Fariñas M4 and Francisco Leyva-Cobián1

1Servicio de Inmunología, Spain

2Banco Regional de Sangre y Tejidos, Comunidad Autónoma de Cantabria, Spain

3Neumología, Hospital Universitario Marqués de Valdecilla-IFIMAV, Santander, Spain

4Unidad de Enfermedades Infecciosas, Hospital Universitario Marqués de Valdecilla-Universidad de Cantabria, Santander, Spain

Corresponding Author:
Gonzalo Ocejo-Vinyals J
Servicio de Inmunología
Hospital Universitario “Marqués de Valdecilla”
39008-Santander, Spain
Tel: +34-942-202941
Fax: +34-942-203847
E-mail: [email protected]

Received Date: September 27, 2013; Accepted Date: November 06, 2013; Published Date: November 14, 2013

Citation: Gonzalo Ocejo-Vinyals J, Ausín F, de Mateo EP, Arroyo JL, Agüero R, et al. (2013) Association of Human Leukocyte Antigens Class I and II Variants with Susceptibility to Pulmonary Tuberculosis in a Caucasian Population from Northern Spain. J Mycobac Dis 3:132. doi:10.4172/2161-1068.1000132

Copyright: © 2013 Gonzalo Ocejo-Vinyals J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Susceptibility to TB seems to be multifactorial, and the development of active disease is probably the result of complex interactions between the host and pathogen, influenced by environmental and genetic factors. The Human Leukocyte Antigen system or HLA seems to be one of these factors. Differences in the distribution of HLA alleles and haplotypes have been found worldwide with conflicting results among different populations and few data concerning Caucasian populations have been reported.

Methods: Distribution of HLA class I and class II alleles was evaluated in 160 Spanish patients with pulmonary tuberculosis, all of them HIV negative, 109 latently infected individuals, and in 262 healthy individuals. All the subjects included in the study belonged to the same geographical area (Cantabria, northern Spain).

Results: HLA-A*02 was found to be significantly more frequent in the latently infected group compared with the control group (34.86% versus 25.19%, p=0.009, OR 0.63 IC95% 0.45-0.89) and with patients with pulmonary tuberculosis (34.86% versus 25.79%, p=0.03, OR 0.65 IC95% 0.45-0.94). HLA-C*08 was found to be significantly more frequent in pulmonary tuberculosis patients compared with the control group (9.69% versus 5.34%, p=0.02, OR 1.91 IC95% 1.12-3.25). HLA-DRB1*04 was found to be significantly more frequent in pulmonary tuberculosis patients compared with the control group (17.19% versus 11.83%, p=0.037, OR 1.55 IC95% 1.04-2.29). Finally, HLA-DRB1*07 was found to be significantly more frequent in healthy and latently infected individuals compared with patients with pulmonary tuberculosis (19.66% & 21.10% versus 3.75%, p=0.036 & 0.034, OR 0.65 & 0.60 IC95% 0.44-0.96 & 0.38-0.94 respectively). The only haplotype which was significantly more frequent in pulmonary tuberculosis patients versus healthy individuals was the DRB1*04-DQA1*03-DQB1*03 extended three locus haplotype (p=0.04, OR 1.53 IC95% 1.03-2.72). All these differences disappeared after statistical correction for multiple comparisons.

Conclusion: Although there were no significant differences in HLA alleles distribution among the three groups after statistical correction, there seems to be a slight trend of certain alleles in conferring protection against or susceptibility to pulmonary tuberculosis, at least in our population.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version