Association of PARL Gene Rs3732581, Rs73887537 Polymorphisms with Type 2 Diabetes Mellitus, Insulin Resistance and Blood Lipid Levels in Chinese Population
|Jing Liu1*, Xiao-feng Huang2, Ju-xiang Liu1, Jin-xing Quan1, Li-min Tian1, Xiao-juan Huang3, Jia Liu1, Yan-jia Xu1, Qi Zhang1, Shu-lan Zhang2, Xiao-hui Chen1 and Rui-lan Niu2|
|1Department of Endocrinology, Gansu Provincial People’s Hospital, 204 West Donggang Road, Lanzhou City 730000, Gansu Province, China|
|2The First Clinical College of Lanzhou University, Lanzhou City 730000, Gansu Province, China|
|3State Key Laboratory for Oxo Synthesis & Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China|
|Corresponding Author :||Jing Liu
Department of Endocrinology
People’s Hospital of Gansu Province
204 West Donggang Road
Lanzhou city 730000, Gansu Province, China
E-mail: [email protected]
|Received December 17, 2013; Accepted January 17, 2014; Published January 24, 2014|
|Citation: Liu J, Huang XF, Liu JX, Quan JX, Tian LM, et al. (2014) Association of PARL Gene Rs3732581, Rs73887537 Polymorphisms with Type 2 Diabetes Mellitus, Insulin Resistance and Blood Lipid Levels in Chinese Population. J Metabolic Synd 3:134. doi:10.4172/2167-0943.1000134|
|Copyright: © 2014 Liu J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Aim: The aim of the current study was to investigate the associations between rs3732581, rs73887537 of PARL gene with type 2 diabetes mellitus and its related phenotypes in Chinese T2DM case-control population.
Methods: We genotyped PARL gene rs3732581, rs73887537 polymorphisms in 543 T2DM patients and 384 healthy controls by using PCR-RFLP technique. Plasma glucose, insulin and lipid were measured by biochemical technique.
Results: rs73887537 polymorphism of PARL gene was not existed in the studied population. The genotype and allele distributions of rs3732581 polymorphism were not significantly different between T2DM and control groups (both P>0.05). However compared with carriers of C allele, the carriers of the GG genotype showed significantly higher levels of triglyceride, total cholesterol in the T2DM and control groups respectively.
Conclusion: rs73887537 polymorphism of PARL gene was not existed in the Chinese studied population. The rs3732581 polymorphism of PARL gene is not associated with the presence of T2DM. However, it is associated with blood lipid levels in T2DM and healthy Chinese population differently.