Association of Physical Activity with Lipodystrophy Syndrome in HIVInfected Patients
3Division of Cardiology, and the National Institute for Science and Technology for Health Technology Assessment (IATS/CNPq), Hospital de Clínicas de Porto Alegre. R. Ramiro Barcelos 2350, Centro de Pesquisas, Cardiolab-Hipertensão, CEP 90035-003, Porto Alegre, RS, Brazil
- *Corresponding Author:
- Sandra C Fuchs
Centro de Pesquisa Clínica
CARDIOLAB-Hipertensão Hospital de Clínicas de Porto Alegre
Universidade Federal do Rio Grande do Sul
Ramiro Barcellos, 2350, 5º andar, 90.035-000
Porto Alegre, RS, Brazil
Tel: + 5551-33597621
Fax: + 5551-3359-8420
E-mail: [email protected]
Received Date: August 28, 2012; Accepted Date: October 18, 2012; Published Date: October 27, 2012
Citation: Trevisol FS, Alencastro PR, Ribeiro PAB, Wollf FH, Ikeda MLR, et al. (2012) Association of Physical Activity with Lipodystrophy Syndrome in HIV-Infected Patients. J AIDS Clinic Res 3:177. doi:10.4172/2155-6113.1000177
Copyright: © 2012 Trevisol FS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Highly Active Antiretroviral Therapy (HAART) has increased life expectancy of HIV-infected patients, but may also increase triglyceride and cholesterol levels, triggering lipodystrophy syndrome. Physical activity may prevent or attenuate such adverse effects, but it has not been fully evaluated in HIV-infected patients. This cross-sectional study aimed to investigate the association between physical activity and lipodystrophy syndrome in HIV-infected individuals, 18 years or older. Physical activity was evaluated by the short version of the International Physical Activity Questionnaire. Lipodystrophy was verified by at least two reporting of changes in different parts of the body, or directly assessed, categorized as lipoatrophy or lipohypertrophy. Among 1,240 participants, 46% had lipohypertrophy, which was independently associated with insufficient physical activity in men, but not in women. The prevalence of lipoatrophy was 53.2%. Metabolic parameters were higher among individuals on HAART, in comparison to HAART-naive patients. In conclusion, HAART-naive physically active individuals had lower metabolic profile than among insufficiently active.