Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample
|Yutao Liu1,2, Jacqueline Rimmler1,2, Michelle F. Dennis3,4, Allison E. Ashley-Koch1,2, Michael A. Hauser1,2, the Mid-Atlantic Mental Illness Research Education and Clinical Center Workgroup#, Jean C. Beckham2,3,4|
|1Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC, USA|
|2Mid-Atlantic Mental Illness Research, Education and Clinical Center (MIRECC), USA|
|3Durham VA Medical Center, Durham, NC, USA|
|4Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA|
|#The Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup for this manuscript includes: Jean C. Beckham, Mira Brancu, Eric B. Elbogen, John A. Fairbank, Jeffrey M. Hoerle, Harold Kudler, Christine E. Marx, Scott D. Moore, Gregory McCarthy, Rajendra Morey, Kristy K. Straits-Tröster, Jennifer L. Strauss, Larry A. Tupler, Richard D. Weiner, and H. Ryan Wagner from the Durham (N.C.) VA Medical Center; Marinell Miller-Mumford from the Hampton (Va.) VA Medical Center; Scott D. McDonald, Antony Fernandez and Treven C. Pickett from the Richmond (Va.) VA Medical Center; Robin A. Hurley, Katherine H. Taber, Cortney L. McCormick and Ruth E. Yoash-Gantz from the Salisbury (N.C.) VA Medical Center|
|*Corresponding Author :||Yutao Liu
Center for Human Genetics
Department of Medicine, Duke University Medical Center
Durham, NC 27710, 595 S. LaSalle Street, DUMC Box 344, USA
E-mail: [email protected]
|Received January 24, 2013; Accepted March 08, 2013; Published March 15, 2013|
|Citation: Liu Y, Rimmler J, Dennis MF, Ashley-Koch AE, Hauser MA, et al. (2013) Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample. J Depress Anxiety S4:001. doi:10.4172/2167-1044.S4-001|
|Copyright: © 2013 Liu Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Backgound: Post traumatic stress disorder (PTSD) is a complex anxiety disorder that can develop after traumatic event exposure. Genetic factors have been associated with PTSD risk. Recently a variant rs4790904 in the protein kinase C alpha (PRKCA) gene has been shown to be associated with PTSD risk. The objective of this study was to replicate this association in a sample of U.S. Afghanistan/Iraq era veterans.
Methods: The genotypes of rs4790904 were evaluated in all trauma-exposed veterans. The sample of U.S. veterans included 428 Caucasians and 533 African-Americans. The statistical analysis was conducted independently in the Caucasian and African-American subjects to evaluate the association with PTSD symptom clusters of B symptoms (reexperiencing), C symptoms (avoidance and numbing), D symptoms (hyperarousal), and with current PTSD diagnosis.
Results: The sample was comprised of 428 Caucasians (186 with current PTSD diagnosis, 242 trauma-exposed controls; median age, 35 years; 15% female) and 533 African-Americans (205 with current PTSD diagnosis, 328 trauma exposed controls; median age, 41 years; 31% female). We observed a significant correlation between rs4790904 and all three PTSD symptom clusters in the Caucasian population, but no significant association with current PTSD diagnosis. However, these significant associations were with the G allele, rather than the A allele, that was previously reported by de Quervain. A significant association of this variant with current PTSD diagnosis (p=0.046) was detected in the African-American veterans.
Conclusion: We confirmed the correlation between rs4790904 and all three PTSD symptom clusters in the Caucasian but not the African-American population. A significant association with a current diagnosis of PTSD was found in the African-American veterans.