alexa Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample
ISSN: 2167-1044

Journal of Depression and Anxiety
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Research Article

Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample

Yutao Liu1,2, Jacqueline Rimmler1,2, Michelle F. Dennis3,4, Allison E. Ashley-Koch1,2, Michael A. Hauser1,2, the Mid-Atlantic Mental Illness Research Education and Clinical Center Workgroup#, Jean C. Beckham2,3,4
1Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC, USA
2Mid-Atlantic Mental Illness Research, Education and Clinical Center (MIRECC), USA
3Durham VA Medical Center, Durham, NC, USA
4Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
#The Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup for this manuscript includes: Jean C. Beckham, Mira Brancu, Eric B. Elbogen, John A. Fairbank, Jeffrey M. Hoerle, Harold Kudler, Christine E. Marx, Scott D. Moore, Gregory McCarthy, Rajendra Morey, Kristy K. Straits-Tröster, Jennifer L. Strauss, Larry A. Tupler, Richard D. Weiner, and H. Ryan Wagner from the Durham (N.C.) VA Medical Center; Marinell Miller-Mumford from the Hampton (Va.) VA Medical Center; Scott D. McDonald, Antony Fernandez and Treven C. Pickett from the Richmond (Va.) VA Medical Center; Robin A. Hurley, Katherine H. Taber, Cortney L. McCormick and Ruth E. Yoash-Gantz from the Salisbury (N.C.) VA Medical Center
*Corresponding Author : Yutao Liu
Center for Human Genetics
Department of Medicine, Duke University Medical Center
Durham, NC 27710, 595 S. LaSalle Street, DUMC Box 344, USA
Tel: (919)684-7090
E-mail: [email protected]
Received January 24, 2013; Accepted March 08, 2013; Published March 15, 2013
Citation: Liu Y, Rimmler J, Dennis MF, Ashley-Koch AE, Hauser MA, et al. (2013) Association of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample. J Depress Anxiety S4:001. doi:10.4172/2167-1044.S4-001
Copyright: © 2013 Liu Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Backgound: Post traumatic stress disorder (PTSD) is a complex anxiety disorder that can develop after traumatic event exposure. Genetic factors have been associated with PTSD risk. Recently a variant rs4790904 in the protein kinase C alpha (PRKCA) gene has been shown to be associated with PTSD risk. The objective of this study was to replicate this association in a sample of U.S. Afghanistan/Iraq era veterans.
Methods: The genotypes of rs4790904 were evaluated in all trauma-exposed veterans. The sample of U.S. veterans included 428 Caucasians and 533 African-Americans. The statistical analysis was conducted independently in the Caucasian and African-American subjects to evaluate the association with PTSD symptom clusters of B symptoms (reexperiencing), C symptoms (avoidance and numbing), D symptoms (hyperarousal), and with current PTSD diagnosis.
Results: The sample was comprised of 428 Caucasians (186 with current PTSD diagnosis, 242 trauma-exposed controls; median age, 35 years; 15% female) and 533 African-Americans (205 with current PTSD diagnosis, 328 trauma exposed controls; median age, 41 years; 31% female). We observed a significant correlation between rs4790904 and all three PTSD symptom clusters in the Caucasian population, but no significant association with current PTSD diagnosis. However, these significant associations were with the G allele, rather than the A allele, that was previously reported by de Quervain. A significant association of this variant with current PTSD diagnosis (p=0.046) was detected in the African-American veterans.
Conclusion: We confirmed the correlation between rs4790904 and all three PTSD symptom clusters in the Caucasian but not the African-American population. A significant association with a current diagnosis of PTSD was found in the African-American veterans.

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