Association Study of Single Nucleotide Polymorphisms in KDM3A and LOC203413 Genes with Male InfertilityPoongothai J*, Jeeva SE and Manonmani S
Department of Biotechnology, PSG College of Technology, Coimbatore, India
- *Corresponding Author:
- Poongothai J
Department of Biotechnology
PSG College of Technology
Tel: +0422 257 2177
E-mail: [email protected]
Received date: September 02, 2016; Accepted date: November 21, 2016; Published date: November 28, 2016
Citation: Poongothai J, Jeeva SE, Manonmani S (2016) Association Study of Single Nucleotide Polymorphisms in KDM3A and LOC203413 Genes with Male Infertility . Andrology (Los Angel) 5:171. doi: 10.4172/2167-0250.1000171
Copyright: © 2016 Poongothai J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A case-control study conducted on fertile and infertile men in Coimbatore population. The study, aimed to identify and associate the following two single nucleotide polymorphisms (SNPs) rs2030259 and rs5911500 in genes KDM3A (lysine (K)-specific demethylase 3A) and LOC203413.The SNPs were identified by restriction fragment length polymorphism (RFLP) technique in 17 normospermic individuals and in 13 infertile males (9 oligospermic and 4 azoospermic) and results were analysed using fisher’s exact test. Although the polymorphisms were found in both fertile and infertile men, no significant association is found for both 2 SNPs with infertility from the samples observed.