Association Study of Single-Nucleotide Polymorphisms on Chromosome 1p13, 1p32, 9p21 and 19p13 with Cardiovascular Diseases in Chinese Han Population: A Case-Control StudyJin Guo1, Yitian Feng1, Habin Li1, Feng Zhang1, Yanxia Luo1, Xiuhua Guo1 and Jialin Hu2*
- *Corresponding Author:
- Jialin Hu, Biology Department
Changchun Normal University
No.3291, Jilin Road, Changchun City
Jilin 130031, China
E-mail : [email protected]
Received Date: December 05, 2016 Accepted Date: December 26, 2016Published Date: December 31, 2016
Citation: Guo J, Feng Y, Li H, Zhang F, Luo Y, et al. (2016) Association Study of Single-Nucleotide Polymorphisms on Chromosome 1p13, 1p32, 9p21 and 19p13 with Cardiovascular Diseases in Chinese Han Population: A Case-Control Study. J Hypertens 5: 233. doi: 10.4172/2167-1095.1000233
Copyright: © 2016 Guo J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objectives: Previous research discovered single nucleotide polymorphism (rs2383206 and rs2383207) on chromosome 9p21 that is associated with coronary heart disease in a Chinese population. However, few data are available on the association of other single nucleotide polymorphism with cardiovascular disease in a Chinese population. This study aimed to determine whether the single nucleotide polymorphisms on chromosome 1p13, 1p32, 9p21 and 19p13 were associated with coronary artery disease in a Chinese population. Methods: We conducted a case-control study. Cases were coronary artery disease (n=670) between 2010 and 2015. Controls (n=1340) were randomly selected and frequency matched to cases on age and gender. All of the participants were selected to study 18 single nucleotides using allele-specific real-time polymerase chain reaction method. Results: Four single nucleotides in 9p21, two single nucleotides in 1p13 and one single nucleotide in 1p32 were associated with cardiovascular disease risk in Chinese population (Global P value for multiple logistic regression, <0.0001, respectively). rs10757274 showing the strongest association with cardiovascular disease. GG carriers of four SNPs (rs10757274, rs2383206, rs10757278 and rs1333049) in 9p21 had higher risk (Odds ratio=1.40, 95% Confidence interval: 1.10-1.79; Odds ratio=1.33, 95% Confidence interval: 1.04-1.69; Odds ratio=1.35, 95% Confidence interval: 1.07-1.72; Odds ratio=1.34, 95% Confidence interval: 1.06-1.71). Conclusion: rs10757274, rs2383206, rs10757278 in 9p21, rs562556 in 1p32, and rs646776 in 1p13 may serve as a novel genetic marker for the risk of significant cardiovascular disease in Chinese Han population.