Associations Between Antibodies Against the Endothelial Cell and T.gondii; Cytomegalovirus in Serum of Children with Cochlear Implant Surgery
- *Corresponding Author:
- Samileh Noorbakhsh
Professor of Pediatric Infectious Diseases
Research Center of Pediatric Infectious Diseases
4th floor Hazrat Rasul Hospital, Niayesh Street, Satarkhan Avenue
Tehran, 14455 Islamic Republic of Iran
E-mail: [email protected]
Received Date: February 26, 2013; Accepted Date: March 22, 2013; Published Date: March 26, 2013
Citation: Noorbakhsh S, Farhadi M, Daneshi A, Tabatabaei A, jomeh EH, et al. (2013) Associations Between Antibodies Against the Endothelial Cell and T. gondii; Cytomegalovirus in Serum of Children with Cochlear Implant Surgery. J AIDS ClinRes 4:197. doi:10.4172/2155-6113.1000197
Copyright: © 2013 Noorbakhsh S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Cytomegalovirus (CMV) and T. gondii are two common causes of SNHL (Sensorineural hearing loss) in Iranian children. Immune-mediated vascular damage induced by endothelial cell antibodies may have a prominent role in sensorineural hearing loss. Objectives: To determine the serum CMV and T. gondii antibodies against endothelial cell in children with profound SNHL and cochlear implant surgery.
Materials & Methods: A cross sectional study was performed on 76 cases with severe SNHL (mean age 32 ± 30.6 months) at cochlear implant ward of Rasoul hospital, Tehran Iran (2008-2010). The titers of antibodies against endothelial cell (Indirect immunofluorescence assay); were determined in sera of 66 cases. Specific antibodies (IgG & IgM) against T. gondi, CMV (Enzyme linked immunosorbent assay) determined in Idiopathic SNHL cases.
Results: Idiopathic type of SNHL was diagnosed in 28.8% (19/66) of younger cases (mean age=20 months; PV=0.05). Positive AECAs was detected in 14.4% (11/76) of cases (with mean age 50 vs. 32 months in cases with negative test; P value=0.047). Positive AECAs had not significant differences between Idiopathic and Non idiopathic type of SNHL [10.5% vs. 9%; PV=0.1]. Positive AECAs were more frequent in cases with known postnatal infections (e.g. mumps, meningitis, chicken pox, etc.) in comparison with non-infection cases (P-value=0.05). Positive T. gondii -IgM (recent infection) was found in 8 /19 (%42); 1 case also had positive T. gondii -IgG. Positive CMV-IgM &IgG were determined in 10 /19 (%52); 17/19 (%89) respectively. A meaningful correlation was observed between positive AECAs and those infections (Toxo, CMV) in Idiopathic (and unclassified) SNHL cases.
Conclusion: Idiopathic type of SNHL with a poor outcome is common (28.8%) in children with cochlear implant surgery Positive AECAs cases had not differences between 2 type of SNHL but were more frequent in older cases with known postnatal infections (meningitis, mumps, chicken pox etc.). A good correlation (p=0.05) between the positive AECAs and known infections determined in studied cases. In contrast, those younger cases (<3 years) with positive AECAs had recent CMV /or T. Gondii (Positive IgM) infections (23 %; 17.7%) without known congenital or acquired type of infections. At least in our country, in younger SNHL cases (<2 year old) due to confirmed recent CMV or T. Gondii infections, application of specific drugs are preferred. Immunosuppressive therapy is only recommended in older cases (>2 year old) with Idiopathic SNHL and concomitant positive AECAs.