alexa Associations between Markers of Glucose and Insulin Fun
ISSN: 2167-7182

Journal of Gerontology & Geriatric Research
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Research Article

Associations between Markers of Glucose and Insulin Function and Cognitive Function in Healthy African American Elders

Jeannine S. Skinner1*, Amy Morgan2, Hector Hernandez-Saucedo3, Angela Hansen2,4, Selena Corbett2, Matthew Arbuckle2, James Leverenz5, Consuelo H. Wilkins1, Suzanne Craft3 and Laura D. Baker3
1Meharry-Vanderbilt Alliance, Vanderbilt University Medical Center, Nashville, Tamil Nadu, India
2Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
3Department of Internal Medicine, and Neurology, Wake Forest University Health Sciences, Winston-Salem, NC, USA
4Division of Gerontology, Geriatric Medicine, University of Washington School of Medicine, USA
5Lou Ruvo Center for Brain Health, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Corresponding Author : Jeannine Skinner PhD
Meharry-Vanderbilt Alliance Vanderbilt University
Medical Center 1005 Dr. D.B. Todd Jr, Boulevard Nashville
TN 37208, USA
Tel: 615-963-2834
E-mail: [email protected]
Received June 30, 2015; Accepted July 20, 2015; Published July 23, 2015
Citation: Skinner JS, Morgan A, Hernandez-Saucedo H, Hansen A, Corbett S (2015) Associations between Markers of Glucose and Insulin Function and Cognitive Function in Healthy African American Elders. J Gerontol Geriat Res 4:232. doi:10.4172/2167-7182.1000232
Copyright: © 2015 Skinner JS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Glucose and insulin are important moderators of cognitive function. African Americans have poorer glycemic control across the glycemic spectrum and are at increased risk for type 2 diabetes and poor cognitive health. It is unclear which glucoregulatory markers predict cognitive function in this at-risk population. The purpose of this study was to examine the association between cognitive function and common markers of glucoregulation in nondiabetic African Americans elders. Methods: Thirty-four, community-dwelling African Americans, aged 50-75 years completed cognitive testing and blood collection as part of a health screening assessment. Cognitive outcomes were composite scores derived from neuropsychological tests of executive function and verbal memory. Linear regression was used to examine relationships between cognitive composite scores and fasting blood levels of glucose, insulin, and hemoglobin A1C, with adjustments for age, education, body mass index, and antihypertensive medication use. Results: Fasting plasma glucose was negatively associated with executive function (β=-0.41, p=0.03). There was a trend of an association between fasting plasma glucose and verbal memory (β=-0.34, p=0.06). Fasting insulin and hemoglobin A1c were not associated with cognitive function. Conclusion: High non-diabetic fasting glucose levels were associated with poorer executive function and verbal memory. These results provide preliminary support for proactive glucose control in older African Americans even before glycemic criteria for type 2 diabetes are met. Our findings suggests that high-normal FPG levels may represent an early red-flag to signify increased risk of cognitive impairment or decline.


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