Associations of Symptomatic or Asymptomatic Peripheral Arterial Disease with All-Cause and Cardiovascular Mortality after 3 Years Follow Up: The China Ankle-Brachial Index Cohort StudyXiankai Li1, Yidong Wei1*, DachunXu1, Yang Han2, Chang Liang1, JianyingShen1, Ji Zhang1, YingyiLuo3, Dayi Hu4, Jue Li4 and YaweiXu1
- *Corresponding Author:
- Yidong Wei
The Department of Cardiology
Shanghai Tenth People’s Hospital
Tongji University School of Medicine
Shanghai, 200072, China
Received Date: July 26, 2013; Accepted Date: August 22, 2013; Published Date: August 24, 2013
Citation: Li X, Wei Y, Xu D, Han Y, Liang C, et al. (2013) Associations of Symptomatic or Asymptomatic Peripheral Arterial Disease with All-Cause and Cardiovascular Mortality after 3 Years Follow Up: The China Ankle-Brachial Index Cohort Study. J Hypertens 2:124. doi:10.4172/2167-1095.1000124
Copyright: © 2013 Li X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: This study aim to investigate all cause and cardiovascular mortality in Chinese in patients with symptomatic or asymptomatic Peripheral Arterial Disease (PAD) in comparison to those without PAD.
Methods: All the subjects were inpatients at high risk of atherosclerosis and consecutively enrolled from July to November, 2004. A total of 3210 were followed up until an end-point was reached or until February 2008.The mean follow-up time was 38 ± 2 months.
Results: Compared with non-PAD, PAD patients had significantly higher frequency of coronary artery disease, hypertension, diabetes mellitus, dyslipidemia, stroke or smoking (all P<0.01). The all cause mortality and cardiovascular mortality in patients with PAD were 25.5% and 15.6%, respectively. Those with symptomatic and asymptomatic PAD had a statistically significant higher all cause and cardiovascular mortality compared to those without PAD (P<0.01).The symptomatic PAD patients were 1.834 times (95% CI: 1.225-2.746) as likely to die as those without PAD, and 1.650 times (95% CI: 1.303-2.088) in asymptomatic PAD patients after adjusting for other factors. Those with symptomatic or asymptomatic PAD had more than twice as likely to die of cardiovascular disease as those without PAD (RR: 2.243, 95% CI: 1.363-3.691 and RR: 2.100, 95% CI: 1.561-2.824, respectively).
Conclusion: In comparison to non-PAD patients, those with PAD were associated with a higher all cause and cardiovascular mortality whether or not PAD is symptomatic. ABI as a marker of atherosclerosis should be routinely done to evaluate PAD in elder patients in China.