alexa Astragaloside IV and Statin Increased the Islet Function and Proliferation for Beta Cells in STZ-Induced Diabetic Mice | OMICS International
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Astragaloside IV and Statin Increased the Islet Function and Proliferation for Beta Cells in STZ-Induced Diabetic Mice

Mincai Li1,2, Tonghui She2, Yapin Gan2, Juan Shao1, Suqin Li2, Wenli Liao2, Hongli Xia3, Liangzu Yu1 and Zhengwu Hu2*

1Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular and Metabolic Disorders, HuBei University of Science and Technology, Xianning 437100, P.R. China

2The Medical School, HuBei University of Science and Technology, Xianning 437100, P.R. China

3Department of Abdominal Surgery, the Central Hospital of Xianning, Xianning 437100, P.R. China

*Corresponding Author:
Zhengwu Hu
The Medical School, Hu Bei University of Science and Technology
Xianning 437100, P.R. China
Tel: 86 27 5975 1111
E-mail: [email protected]; [email protected]

Received date: May 05, 2015; Accepted date: September 29, 2015; Published date: October 02, 2015

Citation: Li M, She T, Gan Y, Shao J, Li S, et al. (2015) Astragaloside IV and Statin Increased the Islet Function and Proliferation for Beta Cells in STZ-Induced Diabetic Mice. J Diabetes Metab 6:611. doi:10.4172/2155-6156.1000611

Copyright: © 2015 Li M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: Diabetic

hyperglycemia

causes a variety of pathological process involved in metabolic changes. Astragaloside IV (AS-IV) was widely used for the treatment of diabetes and cardiovascular diseases in China. The aim of this study was to determine the effect of AS-IV on the function and the proliferation of beta cells in diabetic mice. Methods: We used the immunostaining and

reverse transcription

polymerase chain reaction to detect the expression of insulin, Ki-67 and PDX-1 in pancreatic islets under AS-IV with or without pretreatment with statin in STZ-induced diabetic mice. The inflammation cytokine for TNF-α and MCP-1 expression were detected by ELISA in pancreases in all group mice. Results: AS-IV and statin enhanced the secreted insulin and the proliferation in beta cells and attenuated the increased expression of TNF-α and MCP-1 in diabetic mice. The expression of PDX-1 increased in diabetic mice with AS-IV treatment. Conclusions: Our data suggested that AS-IV enhanced the insulin expression and the islets function through the anti-inflammation and the proliferation pathway in beta cells in

diabetes

and provided a new effect for Chinese traditional drug of AS-IV.

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