alexa Atherogenic and Haematologic Indices of Paracetamol- Overdosed Albino Rats Treated With Aqueous Leaf Extracts of Euphorbia Heterophylla and Jatropha Curcas
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

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Research Article

Atherogenic and Haematologic Indices of Paracetamol- Overdosed Albino Rats Treated With Aqueous Leaf Extracts of Euphorbia Heterophylla and Jatropha Curcas

Chidi Uzoma Igwel*, Linus Nwaogu, Emmanuel Uche Olunkwa, Martin Otaba and Viola Onwuliri

Department of Biochemistry, Federal University of Technology, Owerri, Nigeria

*Corresponding Author:
Chidi Uzoma Igwel
Department of Biochemistry, Federal University of Technology, Owerri, Nigeria
Tel: +234-0806-607-5587/+234-0909-091-8151
E-mail: [email protected]

Received date: March 07, 2017; Accepted date: March 29, 2017; Published date: March 31, 2017

Citation: Igwel CU, Nwaogu L, Olunkwa EU, Otaba M, Onwuliri V (2017) Atherogenic and Haematologic Indices of Paracetamol- Overdosed Albino Rats Treated With Aqueous Leaf Extracts of Euphorbia Heterophylla and Jatropha Curcas. J Clin Toxicol 7:344. doi: 10.4172/2161-0495.1000344

Copyright: © 2016 Mbamalu ON, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: The protective effect of aqueous leaf extracts of Euphorbia Heterophylla and Jatropha Curcas against paracetamol-induced acute changes in lipid, atherogenic and haematologic parameters of albino rats were studied.

Methodology: Twenty-five adult male albino rats weighing 180 to 200 g were randomly assigned into 5 experimental groups (I-V) of five animals each. Group I animals were administered 10 ml of distilled water, while group II rats were given 1000 mg/kg paracetamol. Groups III-V were pretreated with vitamin C (500 mg/kg), E. heterophylla (200 mg/kg) and J.curcas (1000 mg/kg) respectively, 1 h before administration of 1000 mg/kg paracetamol. The animals were orally administered the extracts/drugs daily for 14 days.

Result: Paracetamol administration reduced significantly (p<0.05) the total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and total non HDL-c concentrations as well as white blood cell (WBC) count of the animals when compared with the control. Pre-treatment of the animals with vitamin C non-significantly (p>0.05) countered the observed effects of paracetamol overdose more than the extracts of E. heterophylla and J.curcas. Acute paracetamol overdose did not significantly (p>0.05) affect most of the atherogenic risk predictor indices and haematological parameters studied.

Conclusion: The results indicate that atherogenic and haematologic indices were less responsive than lipid parameters to paracetamol-induced toxicity. Furthermore, aqueous leaf extracts of E. heterophylla and J.curcas had less protective effect than vitamin C against serum lipidaemic changes induced by paracetamol.

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