alexa Atherogenic Index and Female Gender are Independent Determents of Chronic Subclinical Inflammation in Subjects with Type 2 Diabetes Mellitus
ISSN: 2572-5629

Diabetes Case Reports
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Atherogenic Index and Female Gender are Independent Determents of Chronic Subclinical Inflammation in Subjects with Type 2 Diabetes Mellitus

Muhammad Saiedullah1*, Md Mahfuzur Rahman1 and Mohammad Abdul Hai Siddique2,3

1Department of Physiology and Molecular Biology, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh

2Department of Biochemistry and Cell Biology, Bangladesh Institute of Health Sciences (BIHS), Dhaka, Bangladesh

3Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Tohoku University, Sendai, Japan

*Corresponding Author:
Muhammad Saiedullah
Department of Physiology and Molecular Biology
Bangladesh University of Health Sciences (BUHS)
Bangladesh
Tel: 880-2-8055312, 9010654
Fax: 880-2-8055312
E-mail: [email protected], [email protected]

Received date: November 07, 2016; Accepted date: November 25, 2016; Published date: December 05, 2016

Citation: Saiedullah M, Rahman MM, Siddique MAH (2016) Atherogenic Index and Female Gender are Independent Determents of Chronic Subclinical Inflammation in Subjects with Type 2 Diabetes Mellitus. Diabetes Case Rep 1:115. doi: 10.4172/2572-5629.1000115

Copyright: © 2016 Saiedullah M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Chronic subclinical inflammatory poses additional risk of cardiovascular diseases in subjects with type 2 diabetes mellitus (T2DM) but its determinants in Bangladeshi population are not fully resolved. The aim of this study was to explore the relationship between marker of chronic subclinical inflammation and gender and atherogenic index (AI) in subjects with T2DM. Methods: Two hundred and fifty-four subjects with T2DM were included. Demographic and anthropometric variables were estimated. Plasma glucose, serum lipid profile and high sensitivity-C reactive protein (hsCRP) were measured in fasting blood samples using standard methods. AI was calculated as log (concentration of triacylglycerol/high density lipoprotein cholesterol). Results: The median and interquartile range of age was 51 (43-60) years. Of the total subjects, 47% was female and had higher hsCRP [3.1 (1.7-5.6) vs 1.6 (0.84-3.6) mg/L, p<0.0001] but lower AI [0.57 (0.39-0.77) vs 0.68 (0.51- 0.84), p=0.0015] compared to male. Spearman rank correlation coefficient of hsCRP was significant for BMI (ρ=0.204, p=0.0011) and AI (ρ=0.147, p=0.0195). Logistic regression analysis showed significant positive association of AI (β=1.645, p=0.0078) and female gender (β=1.094, p=0.0002) with subclinical inflammation which remained significant (for AI, β=1.548, p=0.0152; for female gender, β=1.086, p=0.0003) on adjusting other confounders (hypertension, lipid lowering drugs). Conclusions: Atherogenic index and female gender were found to be independent determinants of chronic subclinical inflammation.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords