alexa Atrial Remodeling in Permanent Atrial Fibrillation: Mechanisms and Pharmacological Implications
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

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Review Article

Atrial Remodeling in Permanent Atrial Fibrillation: Mechanisms and Pharmacological Implications

Danina M Muntean1, Zsófia Kohajda2,3, Tamás Fazekas4 and Norbert Jost1-3*
1Department of Pathophysiology, University of Medicine and Pharmacy, Timisoara, Romania
2Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary
3Department of Pharmacology & Pharmacotherapy, Faculty of Medicine, University of Szeged, Hungary
4First Department of Internal Medicine, Faculty of Medicine, University of Szeged, Hungary
Corresponding Author : Norbert Jost
Division of Cardiovascular Pharmacology
Hungarian Academy of Sciences and Department of Pharmacology & Pharmacotherapy
Faculty of Medicine, University of Szeged
Dóm tér 12, P.O. Box 427, H-6701 Szeged, Hungary
Tel: (36-62)546885
Fax: (36-62)545680
E-mail: [email protected]
Received: August 13, 2013; Accepted: October 24, 2013; Published: October 28, 2013
Citation: Muntean DM, Kohajda Z, Fazekas T, Jost N (2013) Atrial Remodeling in Permanent Atrial Fibrillation: Mechanisms and Pharmacological Implications. J Clin Exp Cardiolog 4:273. doi:10.4172/2155-9880.1000273
Copyright: © 2013 Muntean DM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Atrial fibrillation (AF), the most prevalent rhythm disorder in clinical practice, is currently significantly contributing to morbidity and mortality of the ageing population. In the past decades, a tremendous amount of research resulted in valuable insights into AF pathophysiology, with a primary focus on atrial remodeling. Defined as a persistent change in atrial function and structure, remodeling has the intrinsic properties to enhance the probability of focal (ectopic) and/or re-entrant pursuits, thus supporting AF persistence. The hallmark of structural remodeling is represented by atrial fibrosis, a multifactorial process involving an interaction between neurohormonal and cellular mediators. This paper provides a brief summary of the recent knowledge with respect to electrical and structural remodeling and novel insights into the pathogenesis of atrial fibrosis. Since current drug options for AF treatment are far from being optimal we also discuss the therapeutic principles and current alternatives for counteracting atrial fibrosis, and thus preventing arrhythmia recurrence.

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