alexa Attempt to Explore the Binding Mechanism of IL-1ÎÂ
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Attempt to Explore the Binding Mechanism of IL-1β Inhibitors via Molecular Docking Studies

Sobia Ahsan Halim1,2* and Muhammad Jawad2

1Department of Biochemistry, Kinnaird College for Women, 93-Jail Road, Lahore, Pakistan

2National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan

*Corresponding Author:
Sobia Ahsan Halim
Department of Biochemistry
Kinnaird College for Women
93-Jail Road, Lahore, Pakistan
Tel: +92 42 99203781-84 extn. 226
E-mail: [email protected]; [email protected]

Received date: September 29, 2015; Accepted date: October 12, 2015; Published date: October 15, 2015

Citation: Halim SA, Jawad M (2015) Attempt to Explore the Binding Mechanism of IL-1β Inhibitors via Molecular Docking Studies. Med chem 5:452-457. doi:10.4172/2161-0444.1000300

Copyright: © 2015 Halim SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

IL-1β is an important cytokineinvolved in several immune responses. IL-1β exerts its effect by binding with its receptorcalled IL-1R1 and leading to a series of intra-cellular signalling. The over-expression of IL-1β leads to immunological complications including arthritis and auto-immune disorders. Currently there are several drugs in the market to cure the inflammation either by inhibiting the production of IL-1β or affecting its signal cascade. The hindrance in the interaction between IL-1β interaction and its receptor can stop its function hence hope to cure inflammatory diseases. This study presents a docking analysis of five commercially available drugs at the IL-1β/IL-1R1 protein interface. This study would give an insight for designing the drugs, capable to block the direct interaction of IL-1β with its receptor ultimately leading to some more consistent cure for inflammatory diseases.

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