Attempt to Explore the Binding Mechanism of IL-1ÃÂ² Inhibitors via Molecular Docking StudiesSobia Ahsan Halim1,2* and Muhammad Jawad2
- *Corresponding Author:
- Sobia Ahsan Halim
Department of Biochemistry
Kinnaird College for Women
93-Jail Road, Lahore, Pakistan
Tel: +92 42 99203781-84 extn. 226
E-mail: [email protected]; [email protected]
Received date: September 29, 2015; Accepted date: October 12, 2015; Published date: October 15, 2015
Citation: Halim SA, Jawad M (2015) Attempt to Explore the Binding Mechanism of IL-1β Inhibitors via Molecular Docking Studies. Med chem 5:452-457. doi:10.4172/2161-0444.1000300
Copyright: © 2015 Halim SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
IL-1β is an important cytokineinvolved in several immune responses. IL-1β exerts its effect by binding with its receptorcalled IL-1R1 and leading to a series of intra-cellular signalling. The over-expression of IL-1β leads to immunological complications including arthritis and auto-immune disorders. Currently there are several drugs in the market to cure the inflammation either by inhibiting the production of IL-1β or affecting its signal cascade. The hindrance in the interaction between IL-1β interaction and its receptor can stop its function hence hope to cure inflammatory diseases. This study presents a docking analysis of five commercially available drugs at the IL-1β/IL-1R1 protein interface. This study would give an insight for designing the drugs, capable to block the direct interaction of IL-1β with its receptor ultimately leading to some more consistent cure for inflammatory diseases.