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ISSN: 2572-0791

Clinical Depression
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Research Article

Attention, Concentration and Planning Ability Improvement in Response to Depression Treatment during Acute Psychiatric Hospitalization

Luba Leontieva1*, Thomas Schwartz1, James L Megna1, Sergey Golovko2, Aadhar Adhlakha3, Lyuba Polinkovsky4, Donald A Cibula5 and Charles Harris6

1Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, USA

2Central New York Psychiatric Center, Marcy, NY, USA

3Detroit Medical Center, Detroit, MI, USA

4Stamford Hospital, Columbia University Family Medicine, CT, USA

5Department of Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY, USA

6St. Lawrence Psychiatric Center, Ogdensburg, NY, USA

*Corresponding Author:
Leontieva L
Department of Psychiatry
SUNY Upstate Medical University
750 East Adams Street
Syracuse, NY, 13210, USA
Tel: 315-464-3278
E-mail: [email protected]

Received Date: May 08, 2017; Accepted Date: May 20, 2017; Published Date: May 27, 2017

Citation: Leontieva L, Schwartz T, Megna JL, Golovko S, Adhlakha A, et al. (2017) Attention, Concentration and Planning Ability Improvement in Response to Depression Treatment during Patient Psychiatric Hospitalization. Clin Depress 3: 123. doi:10.4172/2572-0791.1000123

Copyright: © 2017 Leontieva L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.


Background: Cognitive symptoms are some of the most distressing for patients who are depressed. The goal was to investigate whether depressed patients’ cognition changed depending on treatment with SSRIs (No-NOR) vs. Norepinephrine-enhancing medications (NOR) during an inpatient stay.
Methods: This was an observational, naturalistic, pilot study that used a repeated measures design. 119 depressed inpatients, average age 39 years, 61% females, 77% Caucasian, 74% with mood disorders, 50% Cluster B traits/disorders and 32% psychoactive substance abuse disorders participated. The Trail Making Test (TMT), Hamilton Depression Rating Scale (HDRS), and Outcome Questionnaire-45(OQ-45) were used.
Results: Revealed significant differences between admission and discharge in HDRS (MA=24, MD=9, t (98)=25.30, p<0.001), and OQ-45 (MA=105, MD=72, t (97)=12.91, p<0.001) scores. Mean time to complete the TMT-A at discharge for all NOR patients was 32.92 ± 22.47 seconds, and was significantly shorter than the comparable mean for the No-NOR group (39.10 ± 18.88 seconds, t=-2.33, p=0.022).
Conclusion: Patients taking SNRIs, alone or in combination with benzodiazepines, Seroquel or TCAs (NOR), had significantly shorter completion times for the TMT-A test at discharge than did patients taking SSRIs, with or without benzodiazepines (No-NOR). This cognitive improvement developed independently of significant reductions in depressive symptomatology and interpersonal/social functioning impairment.


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