alexa Attenuation of Hindlimb Ischemia after Associated Autologous Transplantation of Bone Marrow Mononuclear Cells and Platelet Rich Plasma | OMICS International | Abstract
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

Attenuation of Hindlimb Ischemia after Associated Autologous Transplantation of Bone Marrow Mononuclear Cells and Platelet Rich Plasma

Paulo RB Simeoni1, Julio C Francisco1,2,4*, Rossana B Simeoni1, Marco A Cardoso2,3, Ricardo C Cunha4, Bassam F Mogharbel2, Joao C Minozzo1,2, Vivian F do Amaral1, José R Faria-Neto1, Katherine AT Carvalho2 and Luiz C Guarita-Souza1
1Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brasil
2Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Paraná, Brasil
3Universidade Federal do Paraná, Curitiba, Paraná, Brasil
4Universidade Tecnológica Federal do Paraná, Curitiba, Paraná, Brasil
Corresponding Author : Julio Cesar Francisco
Cell Therapy and Biotechnology in Regenerative Medicine Research
The Pelé Pequeno Príncipe Institute
Child and Adolescent Health Research-Av. Silva Jardim, 1632
Curitiba-PR, Brasil CEP 80250-060
Tel: 00554132712133
E-mail: [email protected]
Received: October 09, 2015; Accepted: November 23, 2015; Published: November 26, 2015
Citation: Simeoni PRB, Francisco JC, Simeoni RB, Cardoso MA, Cunha RC, et al. (2015) Attenuation of Hindlimb Ischemia after Associated Autologous Transplantation of Bone Marrow Mononuclear Cells and Platelet Rich Plasma. J Clin Exp Cardiolog 6:409. doi:10.4172/2155-9880.1000409
Copyright: © 2015 Simeoni PRB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Objective: The purpose of this study was to determine whether autologous bone marrow mononuclear stem cell (BMCs) associated with platelet rich plasma (PRP) transplantation improves peripheral collateralization in a rabbit ischemic limb model. Methods: Unilateral hindlimb ischemia was surgically induced in New Zealand White rabbits (n=30). A total of 106 BMCs+PRP were intramuscularly implanted into each ischemic limb. Blood flow was monitored by Doppler in the ischemic and control animals. Histological analysis of capillary density in the ischemic limbs was performed 30 days after the ischemia induction. Results: Histological sections of ischemic gastrocnemius muscle showed that capillary index (capillary/muscle fiber) was greater in the BMCs+PRP implantation group 30 days after the ischemia induction than in the saline group. Conclusion: This study demonstrated that implantation of BMCs+PRP into ischemic limbs effectively induces collateral vessel formation, suggesting that this cell therapy is useful as a novel strategy for therapeutic peripheral arterial disease.

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