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Atypical Granular Cell Tumor of the Larynx: Report of an Unusually Aggressive Tumor | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Case Report

Atypical Granular Cell Tumor of the Larynx: Report of an Unusually Aggressive Tumor

Olfa El Amine Elhadj1, Azza Gabsi1*, Aida Goucha1, Said Gritli2 and Amor Gamoudi1

1Department of Immuno-Histo-Cytology, Salah Azaiez Institute, Tunis, Tunsia

2Department of Oto-Rhino-Laryngology, Salah Azaiez Institute, Tunis, Tunsia

*Corresponding Author:
Azza Gabsi
Department of Immuno-Histo-Cytology
Salah Azaiez Institute Tunis, Tunsia
Tel: 21671563972
E-mail: [email protected]

Received date: March 03, 2017; Accepted date: April 12, 2017; Published date: April 17, 2017

Citation: Amine Elhadj OE, Gabsi A, Goucha A, Gritli S, Gamoudi A (2017) Atypical Granular Cell Tumor of the Larynx: Report of an Unusually Aggressive Tumor. J Cancer Sci Ther 9:405-407. doi: 10.4172/1948-5956.1000450

Copyright: © 2017 Amine Elhadj OE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: Granular cell tumors are uncommon benign neoplasms. The head and neck is the most common site, usually localized to the anterior tongue. The larynx is rarely involved, representing 1.6% to 3.7%.

Case report: We present the case of a 31-year-old, non-smoking female, with a history of recurrent cysts in the pyriform sinus. She consulted for dyspnea. By physical exam, there were no specific findings in head and neck area. Cervical computed tomography demonstrated a tissular mass in the laryngeal area. Laryngoscopy showed a submucosal tumor of the aryepiglottic fold. A biopsy was performed. Histopathological examination revealed round or oval-shaped tumor cells with abundant eosinophilic granular cytoplasm. The nuclei are sometimes small and regular and sometimes hyperchromatic and pleomorphic. The tumor cells showed immunoreactivity for S100 protein and vimentin. The tumor was diagnosed as an atypical granular cell tumor.

Conclusion: Pathologists should be aware of this exceptional lesion. So, that the patient could have appropriate treatment.