Atypical Presentation of Transformed Follicular Lymphoma.
|Dingani Nkosi* and Marie Amanze|
|Visiting Scholar,Florida State University ,College of Medicine, Biomedical dept, Tallahassee, FL, USA|
|Corresponding Author :||Dingani Nkosi
Florida State University College of Medicine,
Tallahassee, FL, USA
E-mail: [email protected]
|Received April 06, 2015; Accepted May 23, 2015; Published May 26, 2015|
|Citation: Nkosi D, Amanze M (2015) Atypical Presentation of Transformed Follicular Lymphoma. J Clin Case Rep 5:531. doi:10.4172/2165-7920.1000531|
|Copyright: © 2015 Nkosi D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Transformation of follicular lymphoma (FL) to Diffuse Large B-Cell Lymphoma (DLBCL) occurs commonly is and associated with a rapidly progressive clinical course that is refractory to treatment and a short survival. The clinical presentation of this transformed disease is variable. We here report a 65 years old man with an atypical presentation of transformed FL. He initially presented with symptoms and clinical signs consistent with Multiple myeloma. His bone marrow biopsy result revealed plasma cell infiltration (CD 138+, CD56-) throughout the marrow. He had a rapid progressive worsening of his condition; he developed liver and renal failure. His imaging studies revealed diffuse lymphadenopathy, an excisional lymph node biopsy done showed FL which had transformed into DLBCL with prominent plasma cell differentiation. He was treated with of R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone) with overall good response but has currently relapsed.