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ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Autoantibodies to Non-myelin Antigens as Contributors to the Pathogenesis of Multiple Sclerosis

Michael C. Levin1,2,3*, Sangmin Lee1,2, Lidia A. Gardner1,2, Yoojin Shin1,2, Joshua N. Douglas1,3 and Chelsea Cooper1,2
1Veterans Administration Medical Center, Memphis, TN, USA
2Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA
3Department of Neuroscience, University of Tennessee Health Science Center, Memphis, TN, USA
Corresponding Author : Michael C. Levin, M.D.
Professor of Neurology
University of Tennessee Health Science Center
Link Building Room 415, 855 Monroe Avenue
Memphis, TN 38163, USA
Tel: 901.523.8990 X6809 (work), 901.448.2243 (work), 901.218.1492 (cell)
Fax: 901.577.7486
E-mail: [email protected]
Received June 03, 2013; Accepted June 24, 2013; Published June 30, 2013
Citation: Levin MC, Lee S, Gardner LA, Shin Y, Douglas JN, et al. (2013) Autoantibodies to Non-myelin Antigens as Contributors to the Pathogenesis of Multiple Sclerosis. J Clin Cell Immunol 4:148. doi:10.4172/2155-9899.1000148
Copyright: © 2013 Levin MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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For years, investigators have sought to prove that myelin antigens are the primary targets of autoimmunity in multiple sclerosis (MS). Recent experiments have begun to challenge this assumption, particularly when studying the neurodegenerative phase of MS. T-lymphocyte responses to myelin antigens have been extensively studied, and are likely early contributors to the pathogenesis of MS. Antibodies to myelin antigens have a much more inconstant association with the pathogenesis of MS. Recent studies indicate that antibodies to non-myelin antigens such as neurofilaments, neurofascin, RNA binding proteins and potassium channels may contribute to the pathogenesis of MS. The purpose of this review is to analyze recent studies that examine the role that autoantibodies to non-myelin antigens might play in the pathogenesis of MS.


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