Autograft Monocytes: The Bad Humors of Autologous Peripheral Blood Hematopoietic Stem Cell TransplantationKerryn Ansell and Luis F Porrata*
Division of Hematology, Department of Internal Medicine, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, USA
- *Corresponding Author:
- Luis F Porrata, MD
Assistant Professor, Mayo Clinic
200 First Street SW, Rochester, Minnesota, 55905, USA
E-mail: [email protected]
Received date: August 23, 2013; Accepted date: October 10, 2013; Published date: October 12, 2013
Citation: Ansell K, Porrata LF (2013) Autograft Monocytes: The Bad Humors of Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation. J Stem Cell Res Ther S3:005. doi:10.4172/2157-7633.S3-005
Copyright: © 2013 Ansell K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Day 15 absolute lymphocyte count (ALC-15) post-autologous peripheral blood hematopoietic stem cell transplantation (APHSCT) is a prognostic factor for survival. ALC-15 recovery post-APHSCT directly depends on the collected and infused autograft absolute lymphocyte count (A-ALC). However, post-APHSCT relapses are still observed despite higher ALC-15 recovery. Recent studies have shown monocyte-derived cells affect tumor progression by suppression of host anti-tumor immunity. Monocytes are also collected and infused in patients undergoing APHSCT. Therefore this article reviews the possible immunosuppressive mechanisms of the autograft absolute monocyte count (A-AMC) affecting the host immunity and survival in patients undergoing APHSCT.