alexa Autoimmune Disease Treatment with Stem Cell Transplantation
ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
Open Access

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Review Article

Autoimmune Disease Treatment with Stem Cell Transplantation

Ming Li and Susumu Ikehara*

Department of Stem Cell Disorders, Kansai Medical University, Hirakata City, Osaka, Japan

*Corresponding Author:
Susumu Ikehara
Department of Stem Cell Disorders
Kansai Medical University
Hirakata City, Osaka 570-1010, Japan
Tel: 81-72-804-2450
Fax: 81-72-804-2454
E-mail: [email protected]

Received date: August 07, 2013; Accepted date:August 30, 2013; Published date: Septetmber 10, 2013

Citation: Li M, Ikehara S (2013) Autoimmune Disease Treatment with Stem Cell Transplantation. J Genet Syndr Gene Ther 4:174. doi:10.4172/2157-7412.1000174

Copyright: © 2013 Li M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Autoimmune Diseases (ADs) are diseases in which the immune system mistakenly attacks and destroys selfmolecules due to a disruption of immunologic tolerance to auto-reactive immune cells. The goals of treatments for ADs are to 1) reduce symptoms, 2) control the autoimmune process and 3) maintain the body’s ability to fight disease. Allogenic Hematopoietic Stem Cell (HSC) transplantation has been shown to be a relatively successful treatment for experimental ADs. Intra Bone Marrow-Bone Marrow Transplantation (IBM-BMT) has been proven to be a powerful strategy for allogeneic BMT due to the rapid hemopoietic recovery and the complete restoration of T cell functions even in donor-recipient combinations across MHC barriers. In this review, we summarize the ADs treatable with IBM-BMT.

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