alexa Autologous Bone Marrow Derived Mononuclear Cell Therapy for Vascular Dementia | OMICS International | Abstract
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
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Case Report

Autologous Bone Marrow Derived Mononuclear Cell Therapy for Vascular Dementia

Sharma A1, Badhe P1, Gokulchandran N1, Kulkarni P2*, Sane H2, Lohia M3, Avhad V2 and Shetty A3

1Department of Medical Services and Clinical research, NeuroGen Brain and Spine Institute, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion-Trombay Road, Chembur, Mumbai, Maharastra, India

2Department of Research and Development, NeuroGen Brain and Spine Institute, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion-Trombay Road, Chembur, Mumbai, Maharastra, India

3Department of NeuroRehablitaion, NeuroGen Brain and Spine Institute, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion-Trombay Road, Chembur, Mumbai, Maharastra, India

*Corresponding Author:
Kulkarni P
Department of Research and Development
NeuroGen Brain and Spine Institute
Surana Sethia Hospital and Research Centre
Suman Nagar, Sion-Trombay Road, Chembur
Mumbai-400071, Maharastra, India
Tel: 022-25281610/25283706
E-mail: [email protected]

Received date October 16, 2012; Accepted date November 02, 2012; Published date November 04, 2012

Citation: Sharma A, Badhe P, Gokulchandran N, Kulkarni P, Sane H, et al. (2012) Autologous Bone Marrow Derived Mononuclear Cell Therapy for Vascular Dementia. J Stem Cell Res Ther 2:129. doi:10.4172/2157-7633.1000129

Copyright: © 2012 Sharma A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Vascular dementia affects a broad spectrum of patients with various manifestations of cognitive decline, which are attributed to cerebral or cardiovascular disease. Laboratory studies have shown that transplanted bone marrow stem cells improve neurological diseases of the central nervous system by generating neural cells or myelin-producing oligodendroglial cells and enhancing neural plasticity. But till now, there has been lack of objective data in the form of investigational findings providing evidence for clinical improvements.

Method: We present a case of a 61 year old woman diagnosed with vascular dementia, who was administered autologous bone marrow derived mononuclear cells, intrathecally.

Result: Even after follow up of 2 years she showed sustained significant clinical improvements recorded by MMSE and FIM along with corroborating changes in PET CT scan of brain showing significantly improved metabolic activity.

Conclusion: Thus, demonstrating objective evidence showing benefits of neuroregeneration rehabilitation therapy in vascular dementia.

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