Autologous Bone Marrow Derived Mononuclear Cell Therapy for Vascular DementiaSharma A1, Badhe P1, Gokulchandran N1, Kulkarni P2*, Sane H2, Lohia M3, Avhad V2 and Shetty A3
1Department of Medical Services and Clinical research, NeuroGen Brain and Spine Institute, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion-Trombay Road, Chembur, Mumbai, Maharastra, India
- *Corresponding Author:
- Kulkarni P
Department of Research and Development
NeuroGen Brain and Spine Institute
Surana Sethia Hospital and Research Centre
Suman Nagar, Sion-Trombay Road, Chembur
Mumbai-400071, Maharastra, India
E-mail: [email protected]
Received date October 16, 2012; Accepted date November 02, 2012; Published date November 04, 2012
Citation: Sharma A, Badhe P, Gokulchandran N, Kulkarni P, Sane H, et al. (2012) Autologous Bone Marrow Derived Mononuclear Cell Therapy for Vascular Dementia. J Stem Cell Res Ther 2:129. doi:10.4172/2157-7633.1000129
Copyright: © 2012 Sharma A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Vascular dementia affects a broad spectrum of patients with various manifestations of cognitive decline, which are attributed to cerebral or cardiovascular disease. Laboratory studies have shown that transplanted bone marrow stem cells improve neurological diseases of the central nervous system by generating neural cells or myelin-producing oligodendroglial cells and enhancing neural plasticity. But till now, there has been lack of objective data in the form of investigational findings providing evidence for clinical improvements.
Method: We present a case of a 61 year old woman diagnosed with vascular dementia, who was administered autologous bone marrow derived mononuclear cells, intrathecally.
Result: Even after follow up of 2 years she showed sustained significant clinical improvements recorded by MMSE and FIM along with corroborating changes in PET CT scan of brain showing significantly improved metabolic activity.
Conclusion: Thus, demonstrating objective evidence showing benefits of neuroregeneration rehabilitation therapy in vascular dementia.