alexa Autologous Bone Marrow Transplantation in Osteonecrosis of the Femoral Head
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

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Research Article

Autologous Bone Marrow Transplantation in Osteonecrosis of the Femoral Head

Ji-hyo Hwang1, Soo-ho Lee*, Ho-youn Park3 and Mi-jung Kim2

1Department of Orthopedic Surgery, Kangnam Sacred Heart Hospital, School of Medicine, Hallym University

2Cell & Molecula Biology Laboratory, Asan Institute for Life Science, Seoul, Korea

3Department of Orthopedic Surgery, Asan Medical Center, School of Medicine, Ulsan University

Corresponding Author:
Dr. Soo-ho Lee
M.D.388-1 Pungnap-2 Dong
Songpa-Gu, Seoul, Korea
Tel: 02-3010-3530
Fax: 02-488-7877
Email: [email protected]

Received date: December 07, 2010; Accepted date: February 12, 2011; Published date: February 14, 2011

Citation: Hwang J, Lee S, Park H, Kim M (2011) Autologous Bone Marrow Transplantation in Osteonecrosis of the Femoral Head. J Tissue Sci Eng 2:103. doi:10.4172/2157-7552.1000103

Copyright: © 2011 Hwang J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Goal: This study evaluated clinical and radiological results of autologous bone marrow transplantation (BMT) for early stage osteonecrosis of the femoral head (ONFH) and analyzed prognostic factors. Materials and Methods: From November 2003 to January 2006, 49 hips in 43 patients with early stage ONFH underwent autologous BMT were followed for at least 2 years. For clinical results, preoperative and postoperative Harris hip score (HSS) were evaluated and survival rate was obtained at the point of performing the total hip arthroplasty. Radiologic results were assessed by changes in necrosis size on MRI performed preoperatively and postoperatively. To evaluate prognostic factors, survival rate was analyzed according to age, gender, etiology, and duration of the symptom.
Results: Postoperative average HHS was significantly increased and there were no significant changes in necrosis size on MRI. Eleven of the 79 hips were required the arthroplasty and the group with use of steroid and short duration of symptom less than 6 months showed lower survival rate.
Conclusion: Autologous BMT for early ONFH can be one of the treatments to improve clinical feature and delay radiologic progress. However the steroid-induced ONFG and short duration of symptom seemed to be poor prognostic factors.


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