Automatic Measurement of Choroidal Thickness with Swept-Source Optical Coherence Tomography for Clinical Follow-Up in Acute Vogt-Koyanagi-Harada DiseaseOlga Garcia-Garcia*, Sara Jordan-Cumplido, Olaia Subira-Gonzalez, Pere Garcia-Bru, Luis Arias, Josep Maria Caminal
Ophthalmology Department, University Hospital of Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
- *Corresponding Author:
- Olga Garcia
Department of Ophthalmology
Hospital Universitari Bellvitge
FeixaLlarga s/n, 08… Hospitalet de Llobregat
E-mail: [email protected]
Received date: June 15, 2016; Accepted date: July 21, 2016; Published date: July 24, 2016
Citation: Garcia-Garcia O, Jordan-Cumplido S, Subira-Gonzalez O, Garcia-Bru P, Arias L, et al. (2016) Automatic Measurement of Choroidal Thickness with Swept-Source Optical Coherence Tomography for Clinical Follow-Up in Acute Vogt-Koyanagi-Harada Disease. J Clin Exp Ophthalmol 7:579. doi:10.4172/2155-9570.1000579
Copyright: © 2016 Garcia-Garcia O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: The course of acute Vogt-Koyanagi-Harada is typically assessed qualitatively using indocyanine green angiography. Swept-source optical coherence tomography may provide a safer, non-invasive, more objective approach to follow up. In this study, we assess the clinical value of the automated measurement capabilities of swept-source tomography to measure choroidal thickness. Design: Prospective, longitudinal case-control study at a tertiary university hospital. Participants: Nine patients with acute Vogt-Koyanagi-Harada disease (18 eyes) and 17 age-matched controls (34 eyes). Methods: Choroidal thickness (subfoveal area and ETDRS grid) was automatically measured with swept-source optical coherence tomography. Changes in thickness were compared to changes in visual acuity and indocyanine green angiography findings to check for correlations. Main outcome measures: Changes in choroidal thickness (micrometers- μm) from baseline. Secondary measures included visual acuity and angiography. Results: At baseline, patients presented significantly greater mean (SD) subfoveal choroidal thickness (666.9 μm [258.3] vs. 302.3 [71.4]) and ETDRS grid choroidal thickness (648.7 μm [260.5] vs. 287.5 [69.3]) than controls (p=0.000). Choroidal thinning and improved vision were associated with treatment while increasing thickness and worsening vision were associated with posterior relapse. In 62.5% of recurrences in tomography, no changes in visual acuity were present; however, all recurrences diagnosed with tomography showed signs of inflammation on angiography. Conclusions: Automatic measurement of choroidal thickness with swept-source optical coherence tomography is a rapid, non-invasive manner of detecting posterior segment recurrences and treatment response in acute Harada patients. Swept-source tomography could reduce the need for angiography to monitor patients with Harada disease.