Autophagic Dysfunction in Type 2 Diabetes Mellitus: Pathophysiology and Therapeutic ImplicationsMd. Tanjir Islam1, Md. Sahab Uddin1*, Kamrun Nahar Lucky1, Md. Manjurul Islam2, Sheik Md. Saiful Islam3, Md. Tanvir Kabir4, Md. Farhad Hossain5, Abdullah Al Mamun1 and Md. Shah Amran6
- Corresponding Author:
- Md. Sahab Uddin
Department of Pharmacy
Southeast University, Dhaka, Bangladesh
E-mail: [email protected]; [email protected]
Received Date: March 29, 2017; Accepted Date: May 19, 2017; Published Date: May 25, 2017
Citation: Islam MT, Uddin MS, Lucky KN, Islam MM, Saiful Islam SM, et al. (2017) Autophagic Dysfunction in Type 2 Diabetes Mellitus: Pathophysiology and Therapeutic Implications. J Diabeteas Metab 8:742. doi:10.4172/2155-6156.1000742
Copyright: © 2017 Islam MT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Autophagy is an intracellular catabolic system by which cells degrade and recycle cytoplasmic constituents such as organelles and proteins through the lysosome-dependent path. Belgian biochemist, Christian de Duve coined the name "autophagy" in 1963. The identification of autophagy-related genes and finally discoveries of mechanisms for autophagy led to the award of the 2016 Nobel Prize in Medicine or Physiology to Japanese cell biologist, Yoshinori Ohsumi specializing in autophagy. Autophagy shows a crucial role in removing aggregated proteins and damaged organelles in order to conserve intracellular homeostasis. In order to control cellular homeostasis and disease states autophagy illustrates a vital role. For insulin resistant patients, insulin secretion and the mass of pancreatic β-cells is increased on account of alterations in the expression and activities of numerous proteins in β-cells. Simultaneously, autophagic activity seems to also be upgraded to adjust to the dynamic changes taking place in β-cells. Actually, faulty autophagy in β-cells recaps a number of features that are perceived in pancreatic islets in the course of the formation of type 2 diabetes mellitus (T2DM). In contrast, the dyregulation of autophagic function is also appears to happen in the β-cells of T2DM patients. Furthermore, autophagy deficiency is linked with the diabetes-related organ dysfunction. Therefore the intention of this study was to provide the impacts of autophagy based on current researches in the development of T2DM and to explore new therapeutic strategies for stopping T2DM pathogenesis.