Autophagy in Toxicology: Defense against XenobioticsWen-Xing Ding*
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
- *Corresponding Author:
- Wen-Xing Ding
Department of Pharmacology
Toxicology and Therapeutics
The University of Kansas Medical Center
MS 1018 3901 Rainbow Blvd, Kansas City
E-mail: [email protected]
Received Date: August 15, 2012; Accepted Date: August 16, 2012; Published Date: August 21, 2012
Citation: Ding WX (2012) Autophagy in Toxicology: Defense against Xenobiotics. J Drug Metab Toxicol 3:e108. doi: 10.4172/2157-7609.1000e108
Copyright: © 2012 Ding WX. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Autophagy is a lysosomal degradation pathway that can degrade cellular proteins and damaged organelles to maintain cellular homeostasis. It is generally agreed that autophagy is a cellular protective mechanism against cell death, but in certain cases, it has been reported that autophagy also contributes to cell death. Although the role of autophagy in toxicology has not been extensively studied, I here discuss the current knowledge regarding the role of autophagy in xenobiotic-induced cell death. I also discuss the role of autophagy in the regulation of redox homeostasis and tumorigenesis.