Autophagy Inhibition to Increase Radiosensitization in Breast CancerDiana Hwang Liang1, Randa El-Zein2 and Bhuvanesh Dave3*
- *Corresponding Author:
- Bhuvanesh Dave
Houston Methodist Cancer Center
Houston Methodist Hospital Research Institute
6670 Bertner Street, Houston
TX 77030, USA
Fax: (713) 441-6287
E-mail: [email protected]
Received date: September 04, 2015 Accepted date:September 26, 2015 Published date:September 28, 2015
Citation: Liang DH, El-Zein R, Dave B (2015) Autophagy Inhibition to Increase Radiosensitization in Breast Cancer. J Nucl Med Radiat Ther 6:254. doi: 10.4172/2155-9619.1000254
Copyright: © 2015 Liang DH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.
Currently, many breast cancer patients with localized breast cancer undergo breast-conserving therapy, consisting of local excision followed by radiation therapy. Following radiation therapy, breast cancer cells are noted to undergo induction of autophagy, development of radioresistance, and enrichment of breast cancer stem cell subpopulations. It is hypothesized that inhibition of the cytoprotective autophagy that arises following radiation therapy increases radiosensitivity and confers longer relapse-free survival by eliminating tumor-initiating breast cancer stem cells. Therefore, we reviewed the controversial role of autophagy in breast cancer tumorigenesis and progression, autophagy induction by radiotherapy, and utilization of autophagy inhibitors to increase radiosensitivity of breast cancer and to target radioresistant breast cancer stem cells.