alexa Autophagy, Paradoxical Functions and Perspective in Can
ISSN: 2471-8556

Oncology & Cancer Case Reports
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Case Report

Autophagy, Paradoxical Functions and Perspective in Cancer Treatment

Qi Li1 and Lu Wang2*
1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, South Street, Dongcheng District, Beijing, 100700, PR China
2Center for Human Disease Genomics, Department of Immunology, School of Basic Medical Science, Peking University Health Science Centre, 38# Xueyuan Road, Haidian District, Beijing, PR China
Corresponding Author : Lu Wang
Center for Human Disease Genomics
Department of Immunology, School of Basic Medical Science
Peking University Health Science Centre
38# Xueyuan Road, Haidian District
Beijing, 100191, PR China
Tel: 86 (10) 82801417
E-mail: [email protected]
Received: November 27, 2015; Accepted: December 15, 2015; Published: December 18, 2015
Citation:Li Q, Wang L (2015) Autophagy, Paradoxical Functions and Perspective in Cancer Treatment. Oncol Cancer Case Rep 1:107. doi:10.4172/2471-8556.1000107
Copyright: © 2015 Li Q, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Autophagy is known as a highly complicated bio-degradative mechanism which closely involves in the regulation of multiple physiological and pathological events such as embryonic development and neuro-degenerative diseases. Strikingly, recent research has highlighted the impact of autophagy on the progression of various kinds of malignancies. It functions as both pro-tumoral and tumor-inhibitory effects in a highly context dependent manner. It induces the autophagic cell death, which is termed as the typeII programmed cell death, in cancer cells. Additionally, through genetic or phamarological methods, the autophagic inducers were reported to efficiently attenuate the angiogenesis and as a result, block the metastasis. In contrast, as a essential regulator for exogeneous and endogeneous stresses, autophagy are proved to be the core response process relating to the chemotherapeutics, which greatly influences the efficacies of clinical treatment and the intensity of drug resistance. Herein, we summarized the current studies of the interaction between autophagy and malignant progression. We also emphasized on the application of the autophagic inhibitors or inducers in clinical practice. Finally, leading by the paradoxical and plastic features of autophagy and its key roles in cancer disease regulation, we made a perspective regarding to the reasonable strategy of autopahgy manipulation in the future cancer treatment.

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