alexa Avocado Extract Inhibits 7, 12-Dimethylbenz[a]anthracen
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Avocado Extract Inhibits 7, 12-Dimethylbenz[a]anthracene (DMBA)- Induced Carcinogenesis in Hamster Cheek Pouches

Haiming Ding1*, Bruce Casto2, Ye Deng3, Kevin Grill2, Wenrui Duan4, Ning Zhang5, Sara Cole6, Krista MD La Perle7, Xueliang Pan8, Douglas Kinghorn A3 and Steven MD'Ambrosio1

1Department of Radiology, College of Medicine, and Comprehensive Cancer Center, The Ohio State University, USA

2College of Public Health, Division of Environmental Health Sciences, and Comprehensive Cancer Center, The Ohio State University, USA

3Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, USA

4College of Medicine, Division of Medical Oncology, and Comprehensive Cancer Center, The Ohio State University, USA

5Department of Neuroscience, College of Medicine, The Ohio State University, USA

6Campus Microscopy & Imaging Facility, The Ohio State University, USA

7Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, USA

8Center for Biostatistics, The Ohio State University, USA

*Corresponding Author:
Haiming Ding
Department of Radiology
College of Medicine, and Comprehensive Cancer Center
The Ohio State University, Room 730 BRT
460 W 12th Avenue, Columbus, OH 43210, USA
Tel: 614-292-2453
Fax: 614-247-5050; E-mail: [email protected]

Received date: May 28, 2014; Accepted date: July 01, 2014; Published date: July 03, 2014

Citation: Ding H, Casto B, Deng Y, Grill K, Duan W, et al. (2014) Avocado Extract Inhibits 7, 12-Dimethylbenz[a]anthracene (DMBA)-Induced Carcinogenesis in Hamster Cheek Pouches. Med chem S1: 008. doi:10.4172/2161-0444.S1-008

Copyright: © 2014 Ding H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background/Aim: Our studies have shown that an avocado extract (D003) selectively inhibits proliferation in premalignant and malignant but not normal primary human oral epithelial cell lines via an ROS-mediated mechanism. Herein, the in vivo anticancer effect of D003 extract and freeze-dried avocado (FA) was determined in the DMBAinitiated hamster cheek pouch (HCP) model.

Materials and Methods: Tumors were initiated in hamster oral mucosa with DMBA followed by topical application of D003, FA, or vehicle. Tumor lesions were counted and evaluated histologically, epithelial proliferation was investigated using MTT assays, and ROS levels in HCP were examined using two photon microscopy.

Results: D003 significantly inhibited tumorigenesis (tumor number and volume) compared to FA and vehicle, but neither D003 nor FA reversed premalignant changes induced by DMBA. ROS levels that were increased in the mucosa by DMBA treatment were enhanced by D003. D003 significantly reduced proliferation of cells in DMBAinitiated mucosa.

Conclusion: Human cell culture and HCP data show that the phytochemicals extracted from avocado exhibit anticancer activity by inhibiting cancer cell proliferation and progression.

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