Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain
- *Corresponding Author:
- OH Gebril
National Research Centre
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Received date: March 07, 2014; Accepted date: March 12, 2014; Published date: March 17, 2014
Citation: Highley JR, Gebril OH, Simpson JE, Wharton SB, Kirby J, et al. (2014) Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain. Aging Sci 2:118. doi: 10.4172/2329-8847.1000118
Copyright: © 2014 Highley JR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cerebral white matters lesions (WML) are seen in 94% of the population aged 64 and over and are associated with cognitive decline and depression. We used immunohistochemistry and stereological methods on post mortem brain samples derived from the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort to investigate the axonal density within deep subcortical lesions. There was no significant difference between the lesional and control white matter, therefore, we conclude that there is axonal preservation within these lesions that are characterized by demyelination.