alexa Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain | OMICS International | Abstract
ISSN: 2329-8847

Journal of Aging Science
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain

JR Highley1, OH Gebril2*, JE Simpson1, SB Wharton1, J Kirby1, F Matthews3, JT O’Brien4, R Barber4, RN Kalaria4, C Brayne5, CE Lewis6, PJ Shaw1 and PG Ince1

1 Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, UK

2 Medical Division, National Research Centre, Cairo, Egypt.

3 MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK

4 Institute for Health and Ageing, University of Newcastle upon Tyne, UK

5 Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

6 Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, UK

*Corresponding Author:
OH Gebril
Medical Division
National Research Centre
Cairo, Egypt
Tel: +2 01157583452
Fax: +2 37791564
E-mail: [email protected]

Received date: March 07, 2014; Accepted date: March 12, 2014; Published date: March 17, 2014

Citation: Highley JR, Gebril OH, Simpson JE, Wharton SB, Kirby J, et al. (2014) Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain. Aging Sci 2:118. doi: 10.4172/2329-8847.1000118

Copyright: © 2014 Highley JR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Cerebral white matters lesions (WML) are seen in 94% of the population aged 64 and over and are associated with cognitive decline and depression. We used immunohistochemistry and stereological methods on post mortem brain samples derived from the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort to investigate the axonal density within deep subcortical lesions. There was no significant difference between the lesional and control white matter, therefore, we conclude that there is axonal preservation within these lesions that are characterized by demyelination.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7