alexa Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain | OMICS International | Abstract
ISSN: 2329-8847

Journal of Aging Science
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Research Article

Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain

JR Highley1, OH Gebril2*, JE Simpson1, SB Wharton1, J Kirby1, F Matthews3, JT O’Brien4, R Barber4, RN Kalaria4, C Brayne5, CE Lewis6, PJ Shaw1 and PG Ince1

1 Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, UK

2 Medical Division, National Research Centre, Cairo, Egypt.

3 MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK

4 Institute for Health and Ageing, University of Newcastle upon Tyne, UK

5 Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

6 Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, UK

*Corresponding Author:
OH Gebril
Medical Division
National Research Centre
Cairo, Egypt
Tel: +2 01157583452
Fax: +2 37791564
E-mail: [email protected]

Received date: March 07, 2014; Accepted date: March 12, 2014; Published date: March 17, 2014

Citation: Highley JR, Gebril OH, Simpson JE, Wharton SB, Kirby J, et al. (2014) Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain. Aging Sci 2:118. doi: 10.4172/2329-8847.1000118

Copyright: © 2014 Highley JR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cerebral white matters lesions (WML) are seen in 94% of the population aged 64 and over and are associated with cognitive decline and depression. We used immunohistochemistry and stereological methods on post mortem brain samples derived from the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort to investigate the axonal density within deep subcortical lesions. There was no significant difference between the lesional and control white matter, therefore, we conclude that there is axonal preservation within these lesions that are characterized by demyelination.

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