alexa Bacillus clausii and Bacillus halodurans lack GlnR but Possess Two Paralogs of glnA
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
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Research Article

Bacillus clausii and Bacillus halodurans lack GlnR but Possess Two Paralogs of glnA

Abbas Farazmand1*, Bagher Yakhchali2, Parvin Shariati2 and Hamideh Ofoghi1

1Department of Biotechnology, Iranian Research Organization for Science and Technology (IROST), 15815-3538, Tehran, Iran

2Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965-161 Tehran, Iran

*Corresponding Author:
Dr. Abbas Farazmand
Department of Biotechnology
Iranian Research Organization for Science and Technology (IROST) 15815- 3538, Tehran, Iran
Tel: (+98) 228 2276636
Fax: (+98) 228 2276636
E-mail: [email protected]

Received Date: July 13, 2011; Accepted Date: September 13, 2011; Published Date: September 21, 2011

Citation: Farazmand A, Yakhchali B, Shariati P, Ofoghi H (2011) Bacillus clausii and Bacillus halodurans lack GlnR but Possess Two Paralogs of glnA. J Proteomics Bioinform 4: 179-183. doi:10.4172/jpb.1000187

Copyright: © 2011 Farazmand A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Bacillus clausii and Bacillus halodurans lack GlnR but possess a single TnrA regulator of nitrogen assimilation and two paralogs of glnA. Bacillus clausii contains two paralogs of the gene encoding the glutamine synthetase (GS), glnA1 (ABC3940) and glnA2 (ABC2179). The glnA1 gene contains a TnrA site. This TnrA site is located downstream of the -10 region of the promoter. However, the glnA2 gene does not contain the TnrA site at its regulatory region. Bacillus haloduranspossesses two paralogs of glnA, both with TnrA-binding sites. The glnA1 (BH2360) gene contains a TnrA site, which overlaps the -10 region of the glnA1 promoter, and the glnA2 (BH3867) gene contains a TnrA site downstream of the -10 region of its promoter. Also, the Bacillus subtilis dicistronic glnRA operon, which encodes GlnR and GS, contains two TnrA sites (glnRAo1 and glnRAo2) in its promoter region. The glnRAo2 site, which overlaps the -35 region of the glnRA promoter, was shown to be required for regulation by TnrA. These results indicate that TnrA regulates the expression of GS, through binds to TnrA sites which overlaps the -35 and -10 promoter elements or lies downstream of the theirs of the glnA or glnRApromoters.


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