Baclofen Treatment for Pain in Nonfunctional Children with Cerebral Palsy - A Brief ReportHilla Ben-Pazi1*, Gila Ben-Shimol2, Ruth David2, Adi Aran3 and Natali Dechtiar2
- *Corresponding Author:
- Ben-Pazi H
Pediatric Movement Disorders, Neuropediatric Unit
Shaare Zedek Medical Center POB 3235, Jerusalem 91031, Israel
E-mail: [email protected]
Received date: January 7, 2016 Accepted date: March 5, 2016 Published date: March 14, 2016
Citation: Ben-Pazi H, Ben-Shimol G, David R, Aran A, Dechtiar N (2016) Baclofen Treatment for Pain in Nonfunctional Children with Cerebral Palsy - A Brief Report. J Pediatr Neurol Med 1:108. doi:10.4172/2472-100X.1000108
Copyright: © 2016 Ben-Pazi H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Baclofen, a GABA-B agonist, reduces hypertonia by increasing spinal inhibition and improves motor function in functional children with cerebral palsy. We hypothesized that oral baclofen reduces pain and improves daily care in nonfunctional children with spastic cerebral palsy. To test this children residing in nursery homes with hypertonia causing pain or interfering with daily care were enrolled in this randomized, double blind, placebo controlled, crossover pilot study. Participants were examined before, during and after 13 weeks of baclofen (2 mg/kg/day) and placebo for pain (Brief Pain Inventory and Dalhousie Pain Survey), ease of care (care and comfort questionnaire) and overall treatment assessment (specific questionnaire, designed for this study). Two participants completed this pilot (ages 7 and 8 years). Pain was reported to interfere less on peak dose of baclofen treatment compared to placebo in one child (p=0.0001) and care tended to be easier in the other (p=0.05). Blinded caregivers recommended continuing baclofen. No significant side effects were reported. Baclofen, an inexpensive safe medication, may alleviate pain in nonfunctional spastic children.