Balancing AhR-Dependent Pro-Oxidant and Nrf2-Responsive Anti-Oxidant Pathways in Age-Related Retinopathy: Is SERPINE1 Expression a Therapeutic Target in Disease Onset and Progression?
Paul J. Higgins*
Center for Cell Biology & Cancer Research, Albany Medical College, Albany, New York 12208
- Corresponding Author:
- Paul J. Higgins
Center for Cell Biology & Cancer Research
Albany Medical College, Albany, New York 12208
E-mail: [email protected]
Received Date: July 15, 2014; Accepted Date: July 17, 2014; Published Date: July 20, 2014
Citation: Higgins PL (2014) Balancing AhR-Dependent Pro-Oxidant and Nrf2-Responsive Anti-Oxidant Pathways in Age-Related Retinopathy: Is SERPINE1 Expression a Therapeutic Target in Disease Onset and Progression?. J Mol Genet Med 08:101. doi:10.4172/1747-0862.1000101
Copyright: © 2014 Higgins PL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Mechanisms underlying the pathophysiology of age-related macular degeneration (AMD), a progressive disease of the retina and a major cause of vision impairment in the elderly, are areas of intense clinical interest. Early-onset AMD is one of the leading causes of blindness in the western world and appears to involve pathologic angiogenesis, unresolving inflammation, oxidative stress and choroidal fibrosis. It is likely that the development of AMD is largely multifactorial involving chronic exposure to xenobiotics, genetic predisposition to initiation and progression, generation of free radicals and an insufficient antioxidant defense system. In this issue of the Journal , Perepechaeva et al.  explore the dysregulation of AhR-Nrf2 “gene batteries” in the retinas of senescence-accelerated OXYS rats during the emergence of an AMD-like retinopathology. The impetus for this work appears to stem from the recent inclusion of genes that encode the arylhydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2), transcription factors essential to the regulation of the global cellular oxidant control program, among the repertoire of candidates that may be involved in either the predisposition to, or development of, AMD.