alexa Barriers to Proceeding to Reduced-Intensity Allogeneic
ISSN: 2329-6917

Journal of Leukemia
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Research Article

Barriers to Proceeding to Reduced-Intensity Allogeneic Stem Cell Transplant in Chronic Lymphocytic Leukemia

Samantha M Jaglowski1*, Susan Geyer1, Nyla A Heerema2, Patrick Elder1, Diane Scholl1, John C Byrd1,3, Steven M Devine1 and Leslie Andritsos1

1Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH, USA

2Division of Cytogenetics, Department of Pathology, The Ohio State University, Columbus, OH, USA

3Division of Medicinal Chemistry, Department of Pharmacy, The Ohio State University, Columbus, OH, USA

*Corresponding Author:
Samantha M Jaglowski, MD
A352 Starling-Loving Hall, 320 W. 10th Avenue
Columbus, OH 43210, USA
Tel: 614-688-7942
E-mail: [email protected]

Received date July 11, 2013; Accepted date August 30, 2013; Published date September 02, 2013

Citation: Jaglowski SM, Geyer S, Heerema NA, Elder P, Scholl D, et al. (2013) Barriers to Proceeding to Reduced-Intensity Allogeneic Stem Cell Transplant in Chronic Lymphocytic Leukemia. J Leuk (Los Angel) 1:121. doi:10.4172/2329-6917.1000121

Copyright: © 2013 Jaglowski SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

To identify potential barriers to reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (ASCT) in patients with chronic lymphocytic leukemia (CLL) we performed a retrospective review of patients referred for transplant consultation at our center. Of the 209 patients evaluated, a substantial proportion of patients who were appropriate candidates for RIC-ASCT were unable to attain disease control to proceed (18.3%) with this therapy. Fludarabine resistance at the time of consultation (p=0.026) and the presence of complex karyotype on metaphase cytogenetics (p=0.048) were observed more frequently among patients unable to receive a transplant, suggesting that the timing of transplant evaluation earlier in the course of treatment for high risk genomic patients is critical for being able to incorporate this treatment modality.

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